Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.
NHC Key Laboratory of Myopia (Fudan University); Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, 200031, China.
Eye (Lond). 2023 Nov;37(16):3313-3321. doi: 10.1038/s41433-023-02510-2. Epub 2023 Apr 5.
The study aimed to compare and rank the accuracy of formulas for calculating intraocular lens (IOL) power in paediatric eyes in a systematic way. A literature search was conducted in Pubmed, Web of Science, Cochrane Library, and EMBASE by December 2021. Combined with traditional and network meta-analysis, we analysed the percentages of paediatric eyes with prediction error (PE) within ±0.50 dioptres (D) and ±1.00 D as the outcome measurements among different formulas. Subgroup analyses stratified by age were also undertaken. Thirteen studies with 1781 eyes comparing 8 calculation formulas were included. For the traditional meta-analysis results, Sanders-Retzlaff-Kraff theoretical (SRK/T) (risk ratios (RR), 1.15; 95% confidence intervals (CI), 1.03-1.30) performed significantly better than the SRKII formula for the percentage of eyes with PE within ±0.50 D. In addition, SRK/T (RR, 1.10; 95% CI, 1.02-1.18) and Holladay 1(RR, 1.15; 95% CI, 1.01-1.30) both performed significantly better than the SRKII formula for the percentage of eyes with PE within ±1.00 D. Considering the ranking based on the surface under the cumulative ranking curve (SUCRA) by Bayesian method, the top four formulas were Barrett Universal II (UII), Haigis, Holladay 1, and SRK/T on the percentage of PE within ±0.50 D, whereas the top four formulas were Barrett UII, Holladay 1, SRK/T, and Hoffer Q formulas on the percentage of PE within ±1.00D. Concerning both outcome measurements of rank probabilities, the top three Barrett UII, SRK/T, and Holladay 1 formulas were considered to provide more accuracy for IOL power calculation in paediatric cataract eyes, and Barrett UII tends to perform better in older children.
本研究旨在系统比较和评估各种计算公式在儿童眼内人工晶状体（IOL）屈光力计算中的准确性。我们于 2021 年 12 月在 Pubmed、Web of Science、Cochrane Library 和 EMBASE 进行了文献检索。通过传统和网络荟萃分析，我们分析了不同公式计算的儿童眼预测误差（PE）在±0.50 屈光度（D）和±1.00 D 范围内的百分比。还进行了按年龄分层的亚组分析。纳入了 13 项比较 8 种计算公式的研究，共 1781 只眼。对于传统荟萃分析结果，Sanders-Retzlaff-Kraff 理论（SRK/T）（风险比（RR），1.15；95%置信区间（CI），1.03-1.30）在预测误差在±0.50 D 范围内的眼数百分比方面显著优于 SRKII 公式。此外，SRK/T（RR，1.10；95% CI，1.02-1.18）和 Holladay 1（RR，1.15；95% CI，1.01-1.30）在预测误差在±1.00 D 范围内的眼数百分比方面均显著优于 SRKII 公式。考虑到基于贝叶斯方法累积排序曲线下面积（SUCRA）的排名，在预测误差在±0.50 D 范围内，排名前四的公式是 Barrett Universal II（UII）、Haigis、Holladay 1 和 SRK/T，而在预测误差在±1.00 D 范围内，排名前四的公式是 Barrett UII、Holladay 1、SRK/T 和 Hoffer Q 公式。对于排名概率的两个结果测量，排名前三位的 Barrett UII、SRK/T 和 Holladay 1 公式被认为在儿童白内障眼中的 IOL 屈光力计算中更准确，Barrett UII 更倾向于在年龄较大的儿童中表现更好。
