Kou Jiaojiao, Chang Pingjun, Lin Lei, Li Zhangliang, Fu Yana, Zhao Yun-E
School of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Key Laboratory of Vision Science, Ministry of Health China, Wenzhou, Zhejiang, China.
J Ophthalmol. 2020 Jul 27;2020:8709375. doi: 10.1155/2020/8709375. eCollection 2020.
This study aims to compare the accuracy of five intraocular lens (IOL) power calculation formulas (SRK/T, Hoffer Q, Holladay 1, Haigis, and Holladay 2) for pediatric eyes in children of different ages.
In this prospective study, patients who received cataract surgery and IOL implantation in the capsular bag were enrolled. We compared the calculation accuracy of 5 formulas at 1 month postoperatively and performed subgroup analysis with the patients divided into three groups according to their ages at the time of surgery as follows: group 1 (age ≤ 2 years, 35 eyes), group 2 (2 years < age < 5 years, 38 eyes), and group 3 (age > 5 years, 29 eyes).
75 patients (102 eyes) were enrolled in this study. The Haigis formula got the smallest PE among all formulas in all three groups. With regard to APE, there were no statistical differences among the formulas except group 2, with the SRK/T formula a little smaller, the Holladay 2 formula a little larger in group 1, and the Haigis formula a little smaller in group 3. In group 2, the Haigis formula had the lowest APE (0.87 ± 0.61 D), while the Holladay 2 formula had the largest (1.71 ± 1.20 D, < 0.001), followed by the Holladay 1 formula (1.51 ± 1.07 D, =0.002). On comparing the percentage of APE within 0.5 D and 1.0 D obtained with 5 formulas in each group, there were no statistical differences. The SRK/T formula and the Holladay 1 formula showed the highest percentage (40.00% and 60.00%) in group 1. While the Haigis formula got the highest percentage in less than 0.5 D (34.21%) and less than 1 D (60.53%) in group 2. In group 3, the Holladay 2 formula and the Haigis formula got the highest percentage less than 0.5 D (58.62%) and less than 1 D (79.31%). The multiple linear regression indicated that the age at the time of surgery was a significant factor affecting the accuracy of APE; after removing the age, AL was the only factor that affected the accuracy of APE.
The SRK/T and the Holladay 1 formulas were relatively accurate in patients younger than 2 years old, while the Haigis formula performed better in patients older than 2.
本研究旨在比较五种人工晶状体（IOL）屈光力计算公式（SRK/T、Hoffer Q、Holladay 1、Haigis和Holladay 2）在不同年龄段儿童眼科中的准确性。
在这项前瞻性研究中，纳入了接受白内障手术并在囊袋内植入人工晶状体的患者。我们比较了术后1个月时5种公式的计算准确性，并根据手术时的年龄将患者分为三组进行亚组分析，如下：第1组（年龄≤2岁，35只眼），第2组（2岁＜年龄＜5岁，38只眼），第3组（年龄＞5岁，29只眼）。
本研究共纳入75例患者（102只眼）。在所有三组中，Haigis公式在所有公式中获得的预测误差（PE）最小。关于平均绝对误差（APE），除第2组外，各公式之间无统计学差异，第1组中SRK/T公式略小，Holladay 2公式略大，第3组中Haigis公式略小。在第2组中，Haigis公式的APE最低（0.87±0.61D），而Holladay 2公式的APE最大（1.71±1.20D，P＜0.001），其次是Holladay 1公式（1.51±1.07D，P = 0.002）。比较每组中5种公式获得的0.5D和1.0D以内APE的百分比，无统计学差异。SRK/T公式和Holladay 1公式在第1组中的百分比最高（分别为40.00%和60.00%）。而Haigis公式在第2组中小于0.5D（34.21%）和小于1D（60.53%）时获得的百分比最高。在第3组中，Holladay 2公式和Haigis公式在小于0.5D（58.62%）和小于1D（79.31%）时获得的百分比最高。多元线性回归表明，手术时的年龄是影响APE准确性的重要因素；去除年龄因素后，眼轴长度（AL）是影响APE准确性的唯一因素。
SRK/T公式和Holladay 1公式在年龄小于2岁的患者中相对准确，而Haigis公式在年龄大于2岁的患者中表现更好。
