Yu Chen, Du Yongjun, Peng Zhi, Ma Chengjie, Fang Junhua, Ma Langtao, Chen Fei, Zhang Chaoqun, Geng Ruizhi, Zhang Yangyang, Han Xi, Li Jiayi, Lv Yan, Lu Sheng
Orthopedics Department, The First People's Hospital of Yunnan Province, Kunming, Yunnan 650034, P.R. China.
Graduate School, Kunming Medical University, Kunming, Yunnan 650500, P.R. China.
Exp Ther Med. 2023 Mar 14;25(4):189. doi: 10.3892/etm.2023.11888. eCollection 2023 Apr.
Osteosarcopenia is a burgeoning geriatric syndrome and a familiar disease among older individuals. It is characterized by reduced skeletal muscle mass and bone mineral density due to osteoporosis and sarcopenia. Its clinical manifestations include reduced physical performance and individuals becoming prone to falls during the aging process resulting in fractures and hospitalization, which seriously affects the quality of life of patients and increases the risk of death. Due to the aging social structure of the global population, the morbidity of osteosarcopenia is expected to continue to increase. Both muscle and bone belong to the motor system and originate from the mesoderm; therefore, sarcopenia and osteoporosis also share similar pathogenical factors, which influence and regulate each other. Studying the pathogenesis and treatment of osteosarcopenia is of great significance to improve the quality of life of patients. Therefore, the present study reviewed the research progress on sarcopenia and osteoporosis in osteosarcopenia from the standpoints of its definition, epidemiology, clinical manifestations and diagnosis, prevention and treatment.
骨少肌少症是一种新兴的老年综合征，在老年人中较为常见。它的特征是由于骨质疏松症和肌少症导致骨骼肌质量和骨矿物质密度降低。其临床表现包括身体机能下降，个体在衰老过程中容易跌倒，进而导致骨折和住院，这严重影响了患者的生活质量并增加了死亡风险。由于全球人口社会结构老龄化，骨少肌少症的发病率预计将持续上升。肌肉和骨骼都属于运动系统，起源于中胚层；因此，肌少症和骨质疏松症也有相似的致病因素，它们相互影响和调节。研究骨少肌少症的发病机制和治疗方法对提高患者生活质量具有重要意义。因此，本研究从骨少肌少症的定义、流行病学、临床表现与诊断、预防和治疗等方面综述了其在骨少肌少症中肌少症和骨质疏松症的研究进展。
