Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region of China; Department of Clinical Oncology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.
Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region of China; Department of Clinical Oncology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China; State Key Laboratory of Oncology in Southern China, Sun Yat-sen University Cancer Center, Guangzhou, China; MOE Key Laboratory of Tumor Molecular Biology, Jinan University, Guangzhou, Guangdong, China; Advanced Nuclear Energy and Nuclear Technology Research Center, Advanced Energy Science and Technology Guangdong Laboratory, Huizhou, Guangdong, China.
Cancer Lett. 2023 May 1;561:216152. doi: 10.1016/j.canlet.2023.216152. Epub 2023 Apr 4.
Ferroptosis is the cell death induced by ferrous ions and lipid peroxidation accumulation in tumor cells. Targeting ferroptosis, which is regulated by various metabolic and immune elements, might become a novel strategy for anti-tumor therapy. In this review, we will focus on the mechanism of ferroptosis and its interaction with cancer and tumor immune microenvironment, especially for the relationship between immune cells and ferroptosis. Also, we will discuss the latest preclinical progress of the collaboration between the ferroptosis-targeted drugs and immunotherapy, and the best potential conditions for their combined use. It will present a future insight on the possible value of ferroptosis in cancer immunotherapy.
铁死亡是铁离子和脂质过氧化物积累在肿瘤细胞中诱导的细胞死亡。针对铁死亡的治疗，其受到多种代谢和免疫因素的调节，可能成为一种新的抗肿瘤治疗策略。在这篇综述中，我们将重点讨论铁死亡的机制及其与癌症和肿瘤免疫微环境的相互作用，特别是免疫细胞与铁死亡之间的关系。此外，我们还将讨论铁死亡靶向药物与免疫治疗联合应用的最新临床前进展，以及联合应用的最佳潜在条件。这将为铁死亡在癌症免疫治疗中的可能价值提供未来的见解。
