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铜死亡相关基因MTF1在泛癌中的预后及免疫作用

Prognostic and Immunological Role of Cuproptosis-Related Gene MTF1 in Pan-Cancer.

作者信息

Zhang Chao, Wang Sifen, Tang Hailin, Lai Renchun, Cai Qiaoting, Su Yaorong, Wu Hao, Huang Yongwen

机构信息

State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou. China.

Jiangmen Central Hospital, Jiangmen 529030, China.

出版信息

J Cancer. 2024 Sep 9;15(17):5786-5809. doi: 10.7150/jca.98749. eCollection 2024.

DOI:10.7150/jca.98749
PMID:39308676
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11414622/
Abstract

Metal regulatory transcription factor 1 (MTF1) has been reported to induce the expression of metallothionein and other genes involved in metal homeostasis. However, the role of MTF1 in pan-cancer and tumor immunity remains unclear. In this study, we conducted a series of bioinformatics analyses to investigate the clinical significance and potential functions of MTF1 across various types of cancer. By employing bioinformatics algorithms and immunofluorescence assays, we analyzed the associations between MTF1 and immune infiltration in the tumor microenvironment as well as the expression levels of immune-related molecules. Our findings revealed dysregulation of MTF1 in pan-cancer along with its correlation with certain clinicopathological features, suggesting its diagnostic and prognostic value for multiple cancer types. Furthermore, our immune-associated analyses and assays demonstrated strong correlations between MTF1 expression and plasmacytoid dendritic cells (pDC), central memory T cells (Tcm), as well as several immune biomarkers. Subsequent in vitro assays indicated that MTF1 reduced the sensitivity of cancer cells to cuproptosis. Overall, our study highlights that MTF1 may serve as a promising biomarker for prognosis assessment and a potential therapeutic target for more effective treatment strategies against various cancers.

摘要

据报道，金属调节转录因子1（MTF1）可诱导金属硫蛋白和其他参与金属稳态的基因的表达。然而，MTF1在泛癌和肿瘤免疫中的作用仍不清楚。在本研究中，我们进行了一系列生物信息学分析，以探讨MTF1在各种癌症类型中的临床意义和潜在功能。通过使用生物信息学算法和免疫荧光测定法，我们分析了MTF1与肿瘤微环境中免疫浸润以及免疫相关分子表达水平之间的关联。我们的研究结果揭示了MTF1在泛癌中的失调及其与某些临床病理特征的相关性，表明其对多种癌症类型的诊断和预后价值。此外，我们的免疫相关分析和测定表明，MTF1表达与浆细胞样树突状细胞（pDC）、中央记忆T细胞（Tcm）以及几种免疫生物标志物之间存在强烈相关性。随后的体外试验表明，MTF1降低了癌细胞对铜死亡的敏感性。总体而言，我们的研究强调，MTF1可能是一种有前途的预后评估生物标志物，也是针对各种癌症制定更有效治疗策略的潜在治疗靶点。

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