Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA.
Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA.
Pharmacol Res. 2023 Jun;192:106757. doi: 10.1016/j.phrs.2023.106757. Epub 2023 Apr 5.
The liver is a major organ that is involved in essential biological functions such as digestion, nutrient storage, and detoxification. Furthermore, it is one of the most metabolically active organs with active roles in regulating carbohydrate, protein, and lipid metabolism. Hepatocellular carcinoma is a cancer of the liver that is associated in settings of chronic inflammation such as viral hepatitis, repeated toxin exposure, and fatty liver disease. Furthermore, liver cancer is the most common cause of death associated with cirrhosis and is the 3rd leading cause of global cancer deaths. LKB1 signaling has been demonstrated to play a role in regulating cellular metabolism under normal and nutrient deficient conditions. Furthermore, LKB1 signaling has been found to be involved in many cancers with most reports identifying LKB1 to have a tumor suppressive role. In this review, we use the KMPlotter database to correlate RNA levels of LKB1 signaling genes and hepatocellular carcinoma patient survival outcomes with the hopes of identifying potential biomarkers clinical usage. Based on our results STRADß, CAB39L, AMPKα, MARK2, SIK1, SIK2, BRSK1, BRSK2, and SNRK expression has a statistically significant impact on patient survival.
肝脏是一个重要的器官，参与许多重要的生理功能，如消化、营养物质储存和解毒。此外，肝脏是新陈代谢最活跃的器官之一，在调节碳水化合物、蛋白质和脂质代谢方面发挥着积极的作用。肝细胞癌是一种与慢性炎症相关的肝癌，如病毒性肝炎、反复毒素暴露和脂肪肝疾病。此外，肝癌是与肝硬化相关的最常见的死亡原因，也是全球癌症死亡的第 3 大主要原因。研究表明 LKB1 信号在正常和营养缺乏条件下调节细胞代谢中发挥作用。此外，LKB1 信号还参与多种癌症，大多数报告表明 LKB1 具有肿瘤抑制作用。在这篇综述中，我们使用 KMPlotter 数据库来关联 LKB1 信号基因的 RNA 水平和肝细胞癌患者的生存结果，希望能确定潜在的临床应用生物标志物。根据我们的结果，STRADß、CAB39L、AMPKα、MARK2、SIK1、SIK2、BRSK1、BRSK2 和 SNRK 的表达对患者的生存有统计学意义上的影响。
