Spahr Hendrik, Hillmann Dierck, Hain Carola, Pfäffle Clara, Sudkamp Helge, Franke Gesa, Hüttmann Gereon
Opt Lett. 2015 Oct 15;40(20):4771-4. doi: 10.1364/OL.40.004771.
We demonstrate a new noninvasive method to assess biomechanical properties of the retinal vascular system. Phase-sensitive full-field swept-source optical coherence tomography (PhS-FF-SS-OCT) is used to investigate retinal vascular dynamics at unprecedented temporal resolution. The motion of retinal tissue that is induced by expansion of the vessels therein is measured with an accuracy of about 10 nm. The pulse shapes of arterial and venous pulsations, their temporal delays, as well as the frequency-dependent pulse propagation through the capillary bed, are determined. For the first time, imaging speed and motion sensitivity are sufficient for a direct measurement of pulse waves propagating with more than 600 mm/s in retinal vessels of a healthy young subject.
我们展示了一种评估视网膜血管系统生物力学特性的新型非侵入性方法。相敏全场扫频光学相干断层扫描（PhS-FF-SS-OCT）用于以前所未有的时间分辨率研究视网膜血管动力学。通过测量其中血管扩张所诱发的视网膜组织运动，其精度约为10纳米。确定了动脉和静脉搏动的脉冲形状、它们的时间延迟，以及通过毛细血管床的频率依赖性脉冲传播。首次实现了成像速度和运动灵敏度足以直接测量健康年轻受试者视网膜血管中以超过600毫米/秒传播的脉搏波。
