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潜在的用于治疗石珊瑚组织损失疾病的益生菌处理的化学和基因组特征。

Chemical and genomic characterization of a potential probiotic treatment for stony coral tissue loss disease.

机构信息

Department of Biology & Marine Biology, University of North Carolina Wilmington, Wilmington, NC, 28403, USA.

Smithsonian Marine Station at Fort Pierce, Fort Piece, FL, 34949, USA.

出版信息

Commun Biol. 2023 Apr 6;6(1):248. doi: 10.1038/s42003-023-04590-y.

DOI:10.1038/s42003-023-04590-y
PMID:37024599
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10079959/
Abstract

Considered one of the most devastating coral disease outbreaks in history, stony coral tissue loss disease (SCTLD) is currently spreading throughout Florida's coral reefs and the greater Caribbean. SCTLD affects at least two dozen different coral species and has been implicated in extensive losses of coral cover. Here we show Pseudoalteromonas sp. strain McH1-7 has broad-spectrum antibacterial activity against SCTLD-associated bacterial isolates. Chemical analyses indicated McH1-7 produces at least two potential antibacterials, korormicin and tetrabromopyrrole, while genomic analysis identified the genes potentially encoding an L-amino acid oxidase and multiple antibacterial metalloproteases (pseudoalterins). During laboratory trials, McH1-7 arrested or slowed disease progression on 68.2% of diseased Montastraea cavernosa fragments treated (n = 22), and it prevented disease transmission by 100% (n = 12). McH1-7 is the most chemically characterized coral probiotic that is an effective prophylactic and direct treatment for the destructive SCTLD as well as a potential alternative to antibiotic use.

摘要

被认为是历史上最具破坏性的珊瑚疾病爆发之一，石珊瑚组织损失疾病（SCTLD）目前正在佛罗里达州的珊瑚礁和更大的加勒比地区蔓延。SCTLD 至少影响了二十几种不同的珊瑚物种，并被认为是珊瑚覆盖范围广泛丧失的原因之一。在这里，我们表明假交替单胞菌菌株 McH1-7 对 SCTLD 相关细菌分离株具有广谱抗菌活性。化学分析表明 McH1-7 至少产生了两种潜在的抗菌物质，即 korormicin 和四溴吡咯，而基因组分析则鉴定了可能编码 L-氨基酸氧化酶和多种抗菌金属蛋白酶（pseudoalterins）的基因。在实验室试验中，McH1-7 阻止或减缓了 68.2%（n=22）患病的 Montastraea cavernosa 片段的疾病进展，并通过 100%（n=12）阻止了疾病传播。McH1-7 是最具化学特征的珊瑚益生菌，它是一种有效的预防性和直接治疗方法，可有效治疗破坏性的 SCTLD，并可作为抗生素使用的替代方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e6e/10079959/2e2ddd2d629a/42003_2023_4590_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e6e/10079959/598b38b33e0d/42003_2023_4590_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e6e/10079959/7bf6864afc4e/42003_2023_4590_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e6e/10079959/50b1d014c5c0/42003_2023_4590_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e6e/10079959/242208dfdac0/42003_2023_4590_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e6e/10079959/2e2ddd2d629a/42003_2023_4590_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e6e/10079959/598b38b33e0d/42003_2023_4590_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e6e/10079959/a79b71bef17a/42003_2023_4590_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e6e/10079959/7bf6864afc4e/42003_2023_4590_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e6e/10079959/50b1d014c5c0/42003_2023_4590_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e6e/10079959/242208dfdac0/42003_2023_4590_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e6e/10079959/2e2ddd2d629a/42003_2023_4590_Fig6_HTML.jpg

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