Wong Kelvin K L, Xu Jinping, Chen Cang, Ghista Dhanjoo, Zhao Hong
The Research Center for Medical AI, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Acupuncture and Moxibustion Department, Luohu District Hospital of Traditional Chinese Medicine, Shenzhen, China.
Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023.
The efficacy of acupuncture and moxibustion in the treatment of depression has been fully recognized internationally. However, its central mechanism is still not developed into a unified standard, and it is generally believed that the central mechanism is regulation of the cortical striatum thalamic neural pathway of the limbic system. In recent years, some scholars have applied functional magnetic resonance imaging (fMRI) to study the central mechanism and the associated brain effects of acupuncture and moxibustion treatment for depression. This study reviews the acupuncture and moxibustion treatment of depression from two aspects: (1) fMRI study of the brain function related to the acupuncture treatment of depression: different acupuncture and moxibustion methods are summarized, the fMRI technique is elaborately explained, and the results of fMRI study of the effects of acupuncture are analyzed in detail, and (2) fMRI associated "brain functional network" effects of acupuncture and moxibustion on depression, including the effects on the hippocampus, the amygdala, the cingulate gyrus, the frontal lobe, the temporal lobe, and other brain regions. The study of the effects of acupuncture on brain imaging is not adequately developed and still needs further improvement and development. The brain function networks associated with the acupuncture treatment of depression have not yet been adequately developed to provide a scientific and standardized mechanism of the effects of acupuncture. For this purpose, this study analyzes in-depth the clinical studies on the treatment of anxiety and depression by acupuncture and moxibustion, by depicting how the employment of fMRI technology provides significant imaging changes in the brain regions. Therefore, the study also provides a reference for future clinical research on the treatment of anxiety and depression.
针灸治疗抑郁症的疗效在国际上已得到充分认可。然而,其核心机制尚未形成统一标准,一般认为其核心机制是对边缘系统的皮质纹状体丘脑神经通路的调节。近年来,一些学者应用功能磁共振成像(fMRI)来研究针灸治疗抑郁症的核心机制及相关脑效应。本研究从两个方面综述针灸治疗抑郁症:(1)抑郁症针灸治疗相关脑功能的fMRI研究:总结不同的针灸方法,详细阐述fMRI技术,并详细分析针灸效应的fMRI研究结果;(2)针灸对抑郁症的fMRI相关“脑功能网络”效应,包括对海马体、杏仁核、扣带回、额叶、颞叶等脑区的影响。针灸对脑成像影响的研究尚不完善,仍需进一步改进和发展。与针灸治疗抑郁症相关的脑功能网络尚未充分发展,无法提供科学规范的针灸效应机制。为此,本研究通过描述fMRI技术的应用如何在脑区产生显著的成像变化,深入分析针灸治疗焦虑症和抑郁症的临床研究。因此,本研究也为未来焦虑症和抑郁症治疗的临床研究提供参考。