单纯性管状乳腺癌：临床病理特征及临床结局

Pure Tubular Breast Carcinoma: Clinicopathological Characteristics and Clinical Outcomes.

作者信息

Emiroglu Selman, Abuaisha Asmaa Mahmoud, Tukenmez Mustafa, Cabioglu Neslihan, Bayram Aysel, Ozmen Vahit, Muslumanoglu Mahmut

机构信息

Breast Surgery Unit, Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Department of Genetics, Institute of Health Sciences, Istanbul University, Istanbul, Turkey.

出版信息

Eur J Breast Health. 2023 Apr 1;19(2):115-120. doi: 10.4274/ejbh.galenos.2023.2022-12-9. eCollection 2023 Apr.

DOI:10.4274/ejbh.galenos.2023.2022-12-9

PMID:37025580

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10071886/

Abstract

OBJECTIVE

Tubular breast carcinoma (TBC) is a rare subtype of breast carcinoma (BC) with a good prognosis. In this study, we aimed to assess the clinicopathological characteristics of pure TBC (PTBC), analyze factors that may influence long-term prognosis, examine the frequency of axillary lymph node metastasis (ALNM), and discuss the need for axillary surgery in PTBC.

MATERIALS AND METHODS

Fifty-four Patients diagnosed with PTBC between January 2003 and December 2020 at Istanbul Faculty of Medicine were included. Clinicopathological, surgical, treatment, and overall survival (OS) data were analyzed.

RESULTS

A total of 54 patients with a mean age of 52.2 years were assessed. The mean size of the tumor was 10.6 mm. Four (7.4%) patients had not undergone axillary surgery, while thirty-eight (70.4%) had undergone sentinel lymph node biopsy and twelve (22.2%) had undergone axillary lymph node dissection (ALND). Significantly, four (33.3%) of those who had undergone ALND had tumor grade 2 ( = 0.020) and eight of them (66.7%) had ALNM. Fifty percent (50%) of patients who were treated with chemotherapy had grade 2 and multifocal tumors and ALNM. Moreover, the frequency of ALNM was higher in patients with tumor diameters greater than 10 mm. Median follow-up time was 80 months (12-220). None of the patients had locoregional recurrence, but one patient had systemic metastasis. Furthermore, five-year OS was 97.9%, while ten-year OS was 93.6%.

CONCLUSION

PTBC is associated with favorable prognosis, good clinical outcomes and high survival rate, with rare recurrences and metastases.

摘要

目的

管状乳腺癌（TBC）是乳腺癌（BC）的一种罕见亚型，预后良好。在本研究中，我们旨在评估纯管状乳腺癌（PTBC）的临床病理特征，分析可能影响长期预后的因素，检查腋窝淋巴结转移（ALNM）的频率，并讨论PTBC患者腋窝手术的必要性。

材料与方法

纳入2003年1月至2020年12月在伊斯坦布尔医学院诊断为PTBC的54例患者。分析临床病理、手术、治疗和总生存（OS）数据。

结果

共评估了54例患者，平均年龄52.2岁。肿瘤平均大小为10.6mm。4例（7.4%）患者未接受腋窝手术，38例（70.4%）接受了前哨淋巴结活检，12例（22.2%）接受了腋窝淋巴结清扫（ALND）。值得注意的是，接受ALND的患者中有4例（33.3%）肿瘤分级为2级（P = 0.020），其中8例（66.7%）有ALNM。接受化疗的患者中有50%有2级和多灶性肿瘤以及ALNM。此外，肿瘤直径大于10mm的患者中ALNM的频率更高。中位随访时间为80个月（12 - 220个月）。所有患者均无局部区域复发，但有1例患者发生远处转移。此外，5年总生存率为97.9%，10年总生存率为93.6%。