Sağdıç Mehmet Furkan, Özaslan Cihangir
Department of Surgical Oncology, Ankara Etlik City Hospital, Ankara, Turkey.
Department of Surgical Oncology, University of Health Sciences Ankara Oncology Training and Research Hospital, Ankara, Turkey.
Breast J. 2025 Mar 9;2025:1179914. doi: 10.1155/tbj/1179914. eCollection 2025.
Breast carcinoma is divided into at least 21 separate histologies, according to the 2019 World Health Organization (WHO) classification. The present study is dedicated to a 5% or rarer group of all breast cancer cases. In this study, we retrospectively considered the data of 4550 patients operated on for breast carcinoma at the Ankara Oncology Training and Research Hospital of the University of Health Sciences between January 2018 and February 2024. Of those cases, 401 were discovered to have rare breast cancer types. We also explored the cases by clinicopathological features, overall survival (OS), and disease-free survival (DFS). Our findings revealed a total of 10 rare breast cancer types in patients explored: mucinous carcinoma, micropapillary carcinoma, papillary group carcinomas, metaplastic carcinoma, neuroendocrine carcinoma, tubular carcinoma, cribriform carcinoma, apocrine carcinoma, acinic cell carcinoma, and secretory carcinoma. While mucinous, tubular, cribriform, papillary group carcinomas, micropapillary, and secretory carcinomas are described as types associated with good prognosis, metaplastic, neuroendocrine, apocrine, and carcinomas are described as types associated with relatively poor prognosis. Scrutinizing the clinicopathological features of rare breast cancer types altogether may be the distinct contribution of this paper to the relevant literature and future research.
根据2019年世界卫生组织（WHO）的分类，乳腺癌至少可分为21种不同的组织学类型。本研究聚焦于所有乳腺癌病例中占比5%或更少的一组病例。在本研究中，我们回顾性分析了2018年1月至2024年2月期间在健康科学大学安卡拉肿瘤培训与研究医院接受乳腺癌手术的4550例患者的数据。在这些病例中，发现401例患有罕见的乳腺癌类型。我们还通过临床病理特征、总生存期（OS）和无病生存期（DFS）对这些病例进行了探究。我们的研究结果显示，在探究的患者中共有10种罕见的乳腺癌类型：黏液癌、微乳头癌、乳头型癌、化生性癌、神经内分泌癌、小管癌、筛状癌、大汗腺癌、腺泡细胞癌和分泌性癌。虽然黏液癌、小管癌、筛状癌、乳头型癌、微乳头癌和分泌性癌被描述为预后良好的类型，但化生性癌、神经内分泌癌、大汗腺癌和腺泡细胞癌被描述为预后相对较差的类型。全面审视罕见乳腺癌类型的临床病理特征可能是本文对相关文献和未来研究的独特贡献。
