Larsson Amila, Regnstrand Tobias, Skott Pia, Mäkitie Outi, Björnsdottir Sigridur, Garming-Legert Karin
Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden.
Public Dental Health Service Stockholm AB, Stockholm, Sweden.
Front Oral Health. 2023 Mar 21;4:1087761. doi: 10.3389/froh.2023.1087761. eCollection 2023.
The present study compared the dental health of patients with X-linked hypophosphatemia (XLH) with healthy age- and gender-matched controls to increase our knowledge of the impact of XLH on oral health.
Twenty-two adult patients with XLH in the Stockholm region of Sweden were referred to the Department of Orofacial Medicine at Karolinska Institutet for an extended clinical and radiological examination. Pre-existing radiologic examinations of 44 healthy age- and gender-matched controls were retrieved from the Department of Oral Radiology, at Karolinska Institutet.
The 22 patients with XLH (15 females, median age 38 years, range 20-71; 7 males, median age 49 years, range 24-67) had a significantly higher number of root-filled teeth compared to healthy controls ( = .001). In the XLH group, females had significantly better oral health than males, especially concerning endodontic and cariological status ( = .01 and .02, respectively). Periodontal status differed non-significantly between the XLH and control groups.
Patients with XLH had a significantly lower oral health status compared to a healthy population especially concerning endodontic conditions. Male patients with XLH had a higher risk of poor oral health compared to female patients with XLH.
本研究比较了X连锁低磷血症（XLH）患者与年龄和性别相匹配的健康对照者的牙齿健康状况，以增进我们对XLH对口腔健康影响的了解。
瑞典斯德哥尔摩地区的22名成年XLH患者被转诊至卡罗林斯卡学院口腔颌面医学系进行全面的临床和放射学检查。从卡罗林斯卡学院口腔放射学系检索了44名年龄和性别相匹配的健康对照者的既往放射学检查资料。
22名XLH患者（15名女性，中位年龄38岁，范围20 - 71岁；7名男性，中位年龄49岁，范围24 - 67岁）与健康对照者相比，根管充填牙的数量显著更多（ = 0.001）。在XLH组中，女性的口腔健康状况明显优于男性，尤其是在牙髓病和龋病状况方面（分别为 = 0.01和0.02）。XLH组和对照组之间的牙周状况差异无统计学意义。
与健康人群相比，XLH患者的口腔健康状况显著较低，尤其是在牙髓病方面。与XLH女性患者相比，XLH男性患者口腔健康不良的风险更高。
