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使用即时检测生物标志物对干眼疾病进行患者分层。

Patient stratification using point of care biomarkers in dry eye disease.

机构信息

Department of Cornea and Refractive Surgery, Narayana Nethralaya, Bengaluru, Karnataka, India.

Department of Cataract and Refractive Surgery, Narayana Nethralaya, Bengaluru, Karnataka, India.

出版信息

Indian J Ophthalmol. 2023 Apr;71(4):1391-1400. doi: 10.4103/IJO.IJO_3363_22.

DOI:10.4103/IJO.IJO_3363_22
PMID:37026271
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10276672/
Abstract

With changes in lifestyle, such as the increasing use of digital screens and rising demand for refractive surgery, dry eye disease has become increasingly prevalent in recent times. While we are equipped with a number of diagnostic modalities and a myriad of treatment forms, ranging from topical medication to procedural therapies, the condition remains an enigma in terms of varied patient satisfaction. An understanding of the molecular basis of a disease may open up new avenues in the customization of its treatment. We attempt to simplify this in the form of a stepwise protocol to incorporate biomarker assays in dry eye management.

摘要

随着生活方式的改变,例如数字屏幕的使用日益增加,以及对屈光手术的需求不断上升,干眼症在最近变得越来越普遍。虽然我们拥有多种诊断方式和多种治疗形式,从局部药物治疗到手术治疗都有,但就不同患者的满意度而言,这种疾病仍然是一个谜。对疾病的分子基础的了解可能为其治疗的定制开辟新途径。我们试图以分步方案的形式简化这一点,将生物标志物检测纳入干眼症管理中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3639/10276672/cb9385d71ab9/IJO-71-1391-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3639/10276672/a390a5ec6ae6/IJO-71-1391-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3639/10276672/91e00ab0c9ab/IJO-71-1391-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3639/10276672/9e83fd2e8279/IJO-71-1391-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3639/10276672/185f4001c54d/IJO-71-1391-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3639/10276672/77aeef949049/IJO-71-1391-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3639/10276672/40d766ff5968/IJO-71-1391-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3639/10276672/f02d6deb8c6f/IJO-71-1391-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3639/10276672/cb9385d71ab9/IJO-71-1391-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3639/10276672/a390a5ec6ae6/IJO-71-1391-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3639/10276672/91e00ab0c9ab/IJO-71-1391-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3639/10276672/9e83fd2e8279/IJO-71-1391-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3639/10276672/185f4001c54d/IJO-71-1391-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3639/10276672/77aeef949049/IJO-71-1391-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3639/10276672/40d766ff5968/IJO-71-1391-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3639/10276672/f02d6deb8c6f/IJO-71-1391-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3639/10276672/cb9385d71ab9/IJO-71-1391-g008.jpg

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Cornea. 2022 Sep 1;41(9):1080-1087. doi: 10.1097/ICO.0000000000002954. Epub 2021 Dec 14.
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Quantification of a panel for dry-eye protein biomarkers in tears: A comparative pilot study using standard ELISA and customized microarrays.
定量分析干眼病蛋白生物标志物在泪液中的表达:使用标准 ELISA 和定制微阵列的对比性初步研究。
Mol Vis. 2021 May 8;27:243-261. eCollection 2021.
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Tear Fluid Angiogenic Factors: Potential Noninvasive Biomarkers for Retinopathy of Prematurity Screening in Preterm Infants.泪液血管生成因子:早产儿视网膜病变筛查的潜在非侵入性生物标志物。
Invest Ophthalmol Vis Sci. 2021 Mar 1;62(3):2. doi: 10.1167/iovs.62.3.2.
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