Labora torio de Investigaciones Infectológicas y Biología Molecular, Infectología, Departamento de Medicina, Hospital de Niños Dr Ricardo Gutiérrez, Gallo 1330, Buenos Aires 1425, Argentina.
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Godoy Cruz 2290, Buenos Aires 1425, Argentina.
Trans R Soc Trop Med Hyg. 2023 Aug 3;117(8):561-568. doi: 10.1093/trstmh/trad013.
During the American epidemic, Zika virus (ZIKV) expanded rapidly through dengue virus (DENV)-endemic regions. We analyzed the presentation of ZIKV infection in patients from the City of Orán, Argentina, and compared some of its features with dengue presentation in the same region.
A retrospective study was conducted at San Vicente de Paul Hospital during 2016-2018. Clinical and demographic characteristics, pre-existing immunity to DENV, viral load and type I interferon (IFN) responses were studied in 63 patients with ZIKV infection.
Clinical manifestations of ZIKV infection were generally mild compared with dengue, although rash (p<0.001) and itching (p<0.001) were significantly more prevalent in ZIKV patients. ZIKV patients aged <15 y manifested relatively mild disease compared with older ZIKV patients, showing a decreased prevalence of headache (p=0.008), retro-orbital pain (p=0.001) and arthralgia (p=0.001). Increased Zika incidence was observed in female patients (60.3%). Serum viral load was low to undetectable in ZIKV patients and was not associated with serum anti-DENV IgG titers. Interferon-α and IFN-β serum levels did not correlate with serum viral load in ZIKV patients.
Clinical presentation of ZIKV and DENV infections is largely overlapping, presenting a challenge for diagnosis and risk assessment for uniquely at-risk populations.
在美国疫情期间，寨卡病毒（ZIKV）在登革热病毒（DENV）流行地区迅速传播。我们分析了来自阿根廷奥兰市的寨卡病毒感染患者的表现，并将其与同一地区登革热的表现进行了比较。
在 2016 年至 2018 年期间，我们对圣文森特德保罗医院进行了回顾性研究。对 63 例寨卡病毒感染患者的临床和人口统计学特征、对 DENV 的预先存在的免疫力、病毒载量和 I 型干扰素（IFN）反应进行了研究。
与登革热相比，寨卡病毒感染的临床表现通常较轻，尽管皮疹（p<0.001）和瘙痒（p<0.001）在寨卡病毒患者中更为常见。年龄<15 岁的寨卡病毒患者与年龄较大的寨卡病毒患者相比，疾病表现相对较轻，头痛（p=0.008）、眶后疼痛（p=0.001）和关节痛（p=0.001）的发生率降低。女性患者中寨卡病毒的发病率较高（60.3%）。寨卡病毒患者的血清病毒载量低至无法检测，与血清抗 DENV IgG 滴度无关。干扰素-α和 IFN-β血清水平与寨卡病毒患者的血清病毒载量无关。
寨卡病毒和 DENV 感染的临床表现大多重叠，这给诊断和对特定高危人群的风险评估带来了挑战。
