左外侧前额叶皮层刺激促进情绪调节中的认知重评的 TMS-EEG 特征。
TMS-EEG signatures of facilitated cognitive reappraisal in emotion regulation by left ventrolateral prefrontal cortex stimulation.
机构信息
School of Communication and Information Engineering, Shanghai University, Shanghai, 200444, China; School of Microelectronics and Control Engineering, Changzhou University, Changzhou, Jiangsu, 213164, China.
Institute of Biomedical Engineering, School of Life Science, Shanghai University, Shanghai, 200444, China; College of International Education, Shanghai University, Shanghai, 200444, China.
出版信息
Neuropsychologia. 2023 Jun 6;184:108560. doi: 10.1016/j.neuropsychologia.2023.108560. Epub 2023 Apr 6.
OBJECTIVE
Left ventrolateral prefrontal cortex (VLPFC) has been demonstrated to be a crucial region involved in the down-regulation of negative affect by cognitive reappraisal. However, the neural evidence of causality is still lacking. The current study was to investigate the contribution of left VLPFC in cognitive reappraisal by using single-pulse transcranial magnetic stimulation (spTMS) and electroencephalogram (EEG).
METHODS
Fifteen participants repeated the cognitive reappraisal task at different TMS settings: no stimulation, spTMS applied at 300 ms after image onset to the left VLPFC, and to the vertex as a control site. EEG and behavioral data were concurrently recorded. TMS-evoked potential (TEP) and late positive potential (LPP) were investigated.
RESULTS
In cognitive reappraisal, left VLPFC stimulation elicited stronger TEPs than vertex stimulation at 180 ms after TMS onset. Increased source activation of TEPs was identified in the precentral gyrus. Emotion regulation by reappraisal enlarged the trough of TEP at stimulation site. The left VLPFC stimulation led to enhanced LPP in cognitive reappraisal, which was negatively correlated with self-reported arousal.
CONCLUSIONS
The TMS stimulation over left VLPFC influences the cognitive reappraisal process by potentiating the neural responses. Accordingly, the cortical region responsible for the execution of cognitive reappraisal is activated. The modulated neural activity is related to the behavioral response. The present study provided neural signatures for the facilitated execution of emotion regulation by left VLPFC stimulation, potentially contributing to the therapeutic protocols for mood disorders.
目的
已证实左侧腹外侧前额叶皮层（VLPFC）是通过认知重评来下调负性情绪的关键区域。然而，其因果关系的神经证据仍然缺乏。本研究旨在通过单次脉冲经颅磁刺激（spTMS）和脑电图（EEG）来探究左侧 VLPFC 在认知重评中的作用。
方法
15 名参与者在不同的 TMS 设置下重复认知重评任务：无刺激、刺激左侧 VLPFC 于图像出现后 300ms 以及刺激顶点作为对照。同时记录 EEG 和行为数据。研究了 TMS 诱发电位（TEP）和晚期正电位（LPP）。
结果
在认知重评中，与顶点刺激相比，左侧 VLPFC 刺激在 TMS 刺激后 180ms 时诱发更强的 TEP。TEP 的源激活在中央前回中增加。通过再评价进行情绪调节会扩大刺激部位 TEP 的低谷。左侧 VLPFC 刺激导致认知重评中的 LPP 增强，与自我报告的唤醒呈负相关。
结论
TMS 刺激左侧 VLPFC 通过增强神经反应来影响认知重评过程。因此，负责执行认知重评的皮质区域被激活。调节后的神经活动与行为反应有关。本研究为左侧 VLPFC 刺激促进情绪调节的执行提供了神经特征，可能为情绪障碍的治疗方案做出贡献。
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