Shanghai Institute for Advanced Communication and Data Science, School of Communication and Information Engineering, Qianweichang College, Shanghai University, Shanghai, 200444, China.
Brainnetome Center and National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, 100089, China.
Cogn Affect Behav Neurosci. 2021 Aug;21(4):793-804. doi: 10.3758/s13415-021-00881-1. Epub 2021 Mar 9.
Neuroimage studies have yielded evidence for a correlation between the left ventrolateral prefrontal cortex (VLPFC) and a specific type of cognitive reappraisal strategy, positive reappraisal. However, evidence is still lacking for a direct relation. We used single-pulse transcranial magnetic stimulation (TMS) over the left VLPFC at different time points to investigate the functional specificity of the left VLPFC in the success of positive reappraisal and the timing at which the left VLPC was involved in positive reappraisal. Fifteen participants engaged in a baseline experiment and in TMS experiments. All participants successfully reduced their negative emotional ratings using positive reappraisal in the baseline experiment. In the TMS experiments, participants performed the same task as in the baseline experiment but single-pulse TMS was applied over the left VLPFC at 300 ms or/and 3,300 ms after stimulus onset, as well as over the vertex as a control stimulation. Valence ratings of negative stimuli increased (unpleasantness reduction) when participants reappraised negative stimuli with TMS stimulation over the left VLPFC, regardless of the timing of the stimulation at 300 ms or/and at 3,300 ms after the stimulus onset, relative to the vertex stimulation and the baseline experiment. Our study provided evidence of the functional specificity of the left VLPFC in regulation of negative emotions using positive reappraisal. The left VLPFC was believed to be involved in different stages of positive reappraisal. The prominent facilitation effect of TMS over the left VLPFC makes it possible to consider potential applications in clinical practice for mood disorders.
神经影像学研究已经为左外侧前额叶皮层（VLPFC）与特定类型的认知重评策略（积极重评）之间的相关性提供了证据。然而，直接关联的证据仍然缺乏。我们使用单脉冲经颅磁刺激（TMS）在不同时间点刺激左 VLPFC，以研究左 VLPFC 在积极重评成功中的功能特异性，以及左 VLPC 何时参与积极重评。15 名参与者参与了基线实验和 TMS 实验。所有参与者在基线实验中都成功地使用积极重评降低了他们的负面情绪评分。在 TMS 实验中，参与者执行与基线实验相同的任务，但在刺激开始后 300 毫秒和 3300 毫秒，以及在顶点处施加单脉冲 TMS，作为对照刺激。当参与者用 TMS 刺激左 VLPFC 重新评价负面刺激时，负面刺激的效价评分增加（不愉快感降低），无论刺激在 300 毫秒还是在刺激后 3300 毫秒施加，与顶点刺激和基线实验相比。我们的研究为左 VLPFC 在使用积极重评调节负面情绪方面的功能特异性提供了证据。左 VLPFC 被认为参与了积极重评的不同阶段。TMS 对左 VLPFC 的显著促进作用使得它有可能在临床实践中考虑用于治疗情绪障碍。
