Departments of Pathology and Anatomy, Eastern Virginia Medical School, Norfolk, Virginia, USA.
Department of Hematology and Oncology, Children's National Hospital, Washington, DC, USA.
Pediatr Dermatol. 2023 Jul-Aug;40(4):751-752. doi: 10.1111/pde.15313. Epub 2023 Apr 7.
Cutaneous myeloid sarcoma is rarely present prior to the diagnosis of congenital acute myeloid leukemia (AML); the former is typically diagnosed with or after the leukemia. We report a 2-day-old male born with multiple cutaneous red to violaceous nodules. Histopathologic and immunohistochemistry findings from a skin nodule were suspicious for myeloid sarcoma. Bone marrow biopsy was initially negative for aberrant blasts; however, at age 4 months, AML with a KMT2A gene rearrangement was identified via bone marrow biopsy.
皮肤髓系肉瘤在先天性急性髓系白血病（AML）诊断之前很少出现；前者通常在白血病出现时或之后被诊断出来。我们报告了一例 2 天大的男性，出生时即出现多个皮肤红色至紫色结节。皮肤结节的组织病理学和免疫组化检查结果提示髓系肉瘤。骨髓活检最初未发现异常原始细胞；然而，在 4 月龄时，通过骨髓活检发现了伴有 KMT2A 基因重排的 AML。
