体力活动对结直肠癌幸存者癌因性疲劳的内容和效果：系统评价和荟萃分析。

AIMS

To review the content and efficacy of physical activity (PA) for cancer-related fatigue (CRF) among colorectal cancer survivors.

DESIGN

Systematic review.

METHODS

A comprehensive search for randomized controlled trials from inception to April 1, 2022, of the following database was performed: EMBASE, PubMed, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang Data and China Biology Medicine (CBM). RevMan5.4 software was used for performing meta-analysis.

RESULTS

A total of eight qualified randomized controlled trials that included 542 survivors were included. PA interventions significantly reduced the CRF (SMD = -0.46; 95% CI: [-0.76, -0.15], Z = 2.67, p = 0.003); Subgroup analysis showed that fatigue was significantly improved when the length of interventions was at least 6 months and the weekly duration of PA was less than 150 min/week (SMD = -0.54; 95% CI: [-0.81, -0.27], Z = 3.87 and p = 0.0001; SMD = -0.67; 95% CI: [-1.15, -0.19], Z = 2.74 and p = 0.006); PA intervention with the length of <6 months and the volume of ≥150 min/week did not reduce fatigue (p > 0.05).

目的

综述结直肠癌幸存者相关疲劳（CRF）的体力活动（PA）内容和效果。

设计

系统综述。

方法

对从开始到 2022 年 4 月 1 日的以下数据库进行了全面的随机对照试验搜索：EMBASE、PubMed、Web of Science、Cochrane 图书馆、中国知网（CNKI）、万方数据和中国生物医学文献数据库（CBM）。使用 RevMan5.4 软件进行荟萃分析。

结果

共纳入 8 项合格的随机对照试验，共纳入 542 名幸存者。PA 干预显著降低了 CRF（SMD=-0.46；95%CI：[-0.76，-0.15]，Z=2.67，p=0.003）；亚组分析显示，干预时间至少 6 个月且 PA 每周持续时间<150min/周时，疲劳显著改善（SMD=-0.54；95%CI：[-0.81，-0.27]，Z=3.87，p=0.0001；SMD=-0.67；95%CI：[-1.15，-0.19]，Z=2.74，p=0.006）；干预时间<6 个月且每周持续时间≥150min/周的 PA 干预并不能降低疲劳（p>0.05）。