Titou Hicham, Bouhamidi Ahmed
Department of Dermatology-Venereology, Avicenne Military Hospital, Al Mouquaouama Avenue, 40000, Marrakech, Morocco.
Clin Exp Med. 2023 Nov;23(7):3751-3758. doi: 10.1007/s10238-023-01056-7. Epub 2023 Apr 8.
Limited data regarding survival of Moroccan patients with mycosis fungoides (MF). To evaluate the clinical profile and long-term outcomes of these patients. A retrospective review of 114 MF cases diagnosed from 1993 to 2022 who were followed up for more than 6 months of diagnosis was performed. Of 114 patients, 71.9% were male and the median age at diagnosis was 56 years. Approximately 64 and 36% of the patients had an early stage and advanced stage, respectively. Median follow-up duration was 56 months, and median duration of symptoms before diagnosis was 31 months. Various subtypes were observed, including mycosis fungoides folliculotropic (12.3%), poikilodermatous (11.4%), and palmaris et plantaris MF (5.3%). The 10-year overall survival was 89% in early-stage patients and 48.8% in advanced-stage patients. Complete response to treatment occurred in 45.6%, stable disease in 16.7% and disease progression in 7.9% of patients. Older age of > 60 years, higher T-stage (T3/T4) and advanced-stage MF were statistically significant in predicting poorer outcomes in MF. Despite delay in diagnosis, most cases of MF in Morocco were diagnosed in early stages. We observed a high proportion of classic MF and favorable prognosis.
关于摩洛哥蕈样肉芽肿（MF）患者生存率的数据有限。为评估这些患者的临床特征和长期预后。对1993年至2022年诊断的114例MF病例进行了回顾性研究，这些病例在诊断后随访时间超过6个月。114例患者中，71.9%为男性，诊断时的中位年龄为56岁。分别约64%和36%的患者处于早期和晚期。中位随访时间为56个月，诊断前症状的中位持续时间为31个月。观察到各种亚型，包括毛囊性蕈样肉芽肿（12.3%）、色素沉着性蕈样肉芽肿（11.4%）和掌跖部蕈样肉芽肿（5.3%）。早期患者的10年总生存率为89%，晚期患者为48.8%。45.6%的患者治疗完全缓解，16.7%病情稳定，7.9%病情进展。年龄>60岁、高T分期（T3/T4）和晚期MF在预测MF预后较差方面具有统计学意义。尽管诊断延迟，但摩洛哥的大多数MF病例在早期被诊断。我们观察到经典MF的比例较高且预后良好。
