Campistol J M, Cases A, Torras A, Soler M, Muñoz-Gómez J, Montoliu J, López-Pedret J, Revert L
Department of Nephrology, Hospital Clinic i Provincial, Barcelona, Spain.
Am J Nephrol. 1987;7(5):390-3. doi: 10.1159/000167505.
Carpal tunnel syndrome, peripheral arthropathy, erosive spondyloarthropathy and lytic bone lesions have all been associated with dialysis amyloidosis. Recent studies indicate that beta 2-microglobulin is the major constituent protein in this new form of amyloidosis. Dialysis amyloidosis was reported to have a local rather than a systemic involvement, although its full extent is yet to be determined. We investigated 3 patients on maintenance hemodialysis with bilateral carpal tunnel syndrome and amyloid arthropathy and found amyloid depositions in several organs. These findings suggest that, in contrast to what had been thought previously, dialysis amyloidosis could have systemic as well as visceral distribution. The amyloid deposits found were resistant against potassium permanganate treatment and reacted with anti-human beta 2-microglobulin antibody.
腕管综合征、外周关节病、侵蚀性脊椎关节病和溶骨性骨病变均与透析相关性淀粉样变性有关。最近的研究表明，β2-微球蛋白是这种新型淀粉样变性的主要构成蛋白。据报道，透析相关性淀粉样变性主要累及局部而非全身，尽管其全部范围尚待确定。我们对3例维持性血液透析且患有双侧腕管综合征和淀粉样关节病的患者进行了研究，发现多个器官存在淀粉样蛋白沉积。这些发现表明，与之前的认识相反，透析相关性淀粉样变性可能具有全身及内脏分布。所发现的淀粉样蛋白沉积物对高锰酸钾处理具有抗性，并与抗人β2-微球蛋白抗体发生反应。
