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神经囊尾蚴病:使用吡喹酮的手术及药物治疗

Neurocysticercosis: surgical and medical management with praziquantel.

作者信息

Leblanc R, Knowles K F, Melanson D, MacLean J D, Rouleau G, Farmer J P

出版信息

Neurosurgery. 1986 Apr;18(4):419-27. doi: 10.1227/00006123-198604000-00005.

DOI:10.1227/00006123-198604000-00005
PMID:3703211
Abstract

Eight cases of neurocysticercosis were encountered at the two major neurological centers affiliated with McGill University in Montreal in 4 years. All patients were immigrants who had been in Canada for a period of 1 to 18 years and came from South America (three cases), Haiti (three cases), and Greece (two cases). Five patients had parenchymal cysts and presented with epilepsy; three had the racemose form and presented with hydrocephalus. Four patients with parenchymal cysts were treated by removal of the cysticercus and did well. One patient with numerous cysts was treated with praziquantel with good clinical and radiological results. Two patients with the racemose form were treated by cyst aspiration, cerebrospinal fluid (CSF) diversion, and praziquantel and did well. Another patient with the racemose form, seen before the advent of praziquantel, died of cysticercosis infection. Neurocysticercosis is not uncommon in the immigrant population of large North American cities. Single symptomatic cysts can be evacuated surgically with good results; multiple parenchymatous cysts can be treated with praziquantel. Patients with the racemose form who are treated with CSF diversion and praziquantel do well, although those who are only treated surgically die of their disease.

摘要

在4年时间里,蒙特利尔麦吉尔大学附属的两家主要神经科中心共接诊了8例神经囊尾蚴病患者。所有患者均为移民,在加拿大居住了1至18年,分别来自南美洲(3例)、海地(3例)和希腊(2例)。5例患者为实质囊肿型,表现为癫痫;3例为葡萄状型,表现为脑积水。4例实质囊肿型患者通过摘除囊尾蚴进行治疗,效果良好。1例有大量囊肿的患者接受吡喹酮治疗,临床和影像学结果良好。2例葡萄状型患者通过囊肿抽吸、脑脊液分流及吡喹酮治疗,效果良好。另1例葡萄状型患者在吡喹酮问世前就诊,死于囊尾蚴感染。神经囊尾蚴病在北美大城市的移民人群中并不罕见。单个有症状的囊肿可通过手术摘除,效果良好;多个实质囊肿可用吡喹酮治疗。接受脑脊液分流和吡喹酮治疗的葡萄状型患者效果良好,而仅接受手术治疗的患者会死于该病。

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1
Neurocysticercosis: surgical and medical management with praziquantel.神经囊尾蚴病:使用吡喹酮的手术及药物治疗
Neurosurgery. 1986 Apr;18(4):419-27. doi: 10.1227/00006123-198604000-00005.
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Neurocysticercosis treated with praziquantel. Long-term follow-up of a case.
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Praziquantel in the treatment of neurocysticercosis: long-term follow-up.吡喹酮治疗神经囊尾蚴病:长期随访
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Long-term results of praziquantel therapy in neurocysticercosis.
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[Neurocysticercosis].[神经囊尾蚴病]
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[Selective sensitivity of cysts to praziquantel and albendazole in a case of cerebral cysticercosis].[脑囊尾蚴病病例中囊肿对吡喹酮和阿苯达唑的选择性敏感性]
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Current consensus guidelines for treatment of neurocysticercosis.神经囊尾蚴病治疗的当前共识指南。
Clin Microbiol Rev. 2002 Oct;15(4):747-56. doi: 10.1128/CMR.15.4.747-756.2002.
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High-dose praziquantel with cimetidine for refractory neurocysticercosis: a case report with clinical and MRI follow-up.大剂量吡喹酮联合西咪替丁治疗难治性神经囊尾蚴病:1例临床及MRI随访病例报告
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Praziquantel treatment of porcine brain and muscle Taenia solium cysticercosis. 1. Radiological, physiological and histopathological studies.
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