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妇科肿瘤学中抗体药物偶联物的眼部毒性及缓解策略

Ocular toxicity and mitigation strategies for antibody drug conjugates in gynecologic oncology.

作者信息

Richardson Debra L

机构信息

Associate Professor and Section Chief, Division of Gynecologic Oncology, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, 800 NE 10th St, Oklahoma City, OK 73104, USA.

出版信息

Gynecol Oncol Rep. 2023 Feb 9;46:101148. doi: 10.1016/j.gore.2023.101148. eCollection 2023 Apr.

DOI:10.1016/j.gore.2023.101148
PMID:37033209
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10073635/
Abstract

Recently, two antibody drug conjugates were FDA approved for the treatment of recurrent gynecologic malignancies. Both of these new agents are associated with ocular toxicity. Ocular toxicity can be prevented and mitigated by utilizing recommended eye care strategies.

摘要

最近,两种抗体药物偶联物被美国食品药品监督管理局(FDA)批准用于治疗复发性妇科恶性肿瘤。这两种新药都与眼部毒性有关。通过采用推荐的眼部护理策略,可以预防和减轻眼部毒性。

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J Clin Oncol. 2023 May 1;41(13):2436-2445. doi: 10.1200/JCO.22.01900. Epub 2023 Jan 30.
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Lancet Oncol. 2021 May;22(5):609-619. doi: 10.1016/S1470-2045(21)00056-5. Epub 2021 Apr 9.
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Phase III, randomized trial of mirvetuximab soravtansine versus chemotherapy in patients with platinum-resistant ovarian cancer: primary analysis of FORWARD I.III 期随机临床试验:索拉非尼单药治疗与化疗用于铂耐药卵巢癌患者的比较:FORWARD I 研究的主要分析。
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