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与富含亮氨酸胶质瘤失活蛋白(LGI1)边缘性脑炎相关的运动现象

Motor Phenomena Associated With Leucine-Rich Glioma-Inactivated (LGI1) Emi-Encephalitis.

作者信息

Giorelli Maurizio, Aniello Maria S, Altomare Sergio, Leone Ruggiero, Liuzzi Daniele

机构信息

Operative Unit of Neurology, "Dimiccoli" General Hospital, Barletta, ITA.

出版信息

Cureus. 2023 Mar 7;15(3):e35882. doi: 10.7759/cureus.35882. eCollection 2023 Mar.

Abstract

LGI1 encephalitis is a rare immune-mediated brain disorder. Its typical features include faciobrachial dystonic seizures (FBDS), startle reactions, chorea, myoclonus, atypical parkinsonism, cogni-tive impairment, and personality changes. We report the case of a 57-year-old woman presenting with distinct patterns of involuntary movements, including faciobrachial dystonic spasms, dyskinetic movements, and chorea. Magnetic resonance imaging (MRI) and tests on blood and cerebrospinal fluid (CSF) demonstrated encephalitis involving the right temporal lobe and caudate nucleus and associated with LGI1-antibody. LGI1 encephalitis may present with simultaneous distinct patterns of movement disorders depending on the cortical and subcortical structures involved in the disease.

摘要

LGI1 脑炎是一种罕见的免疫介导性脑部疾病。其典型特征包括面臂肌张力障碍性癫痫发作(FBDS)、惊吓反应、舞蹈症、肌阵挛、非典型帕金森综合征、认知障碍和人格改变。我们报告了一例 57 岁女性病例,其出现了不同类型的不自主运动,包括面臂肌张力障碍性痉挛、运动障碍性运动和舞蹈症。磁共振成像(MRI)以及血液和脑脊液(CSF)检查显示为累及右侧颞叶和尾状核的脑炎,并与 LGI1 抗体相关。LGI1 脑炎可能会根据疾病所累及的皮质和皮质下结构,同时出现不同类型的运动障碍。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aaa8/10080185/c1acf3bd8dc8/cureus-0015-00000035882-i01.jpg

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