English Jospeh C, Derdeyn Amalie S, Wilson Wendy M, Patterson James W
Department of Dermatology and Pathology, University of Virginia Health System, Charlottesville 22908-0718, USA.
J Cutan Med Surg. 2003 Jul-Aug;7(4):330-2. doi: 10.1007/s10227-002-0131-4.
Granular parakeratosis is a hyperkeratotic eruption of unknown etiology that occurs in the axilla and other intertriginous areas. The histologic features are unique for the retention of keratohyalin granules in the stratum corneum.
The aim of the article is to review the clinical manifestations and treatment of granular parakeratosis.
A case report and literature review are presented.
Twenty-six cases of granular parakeratosis now have been reported and reviewed.
Granular parakeratosis occurs predominantly in middle age women and most frequently in the axilla. A number of treatments have been applied to the 26 cases reported to date, without consistent responses. No evidence-based therapy can be suggested at present.
颗粒状角化不全是一种病因不明的角化过度性皮疹，发生于腋窝及其他间擦部位。其组织学特征为角质层中透明角质颗粒的保留，具有独特性。
本文旨在综述颗粒状角化不全的临床表现及治疗方法。
本文呈现了一例病例报告并进行文献复习。
目前已报告并复习了26例颗粒状角化不全病例。
颗粒状角化不全主要发生于中年女性，最常见于腋窝。对于迄今报告的26例病例已应用了多种治疗方法，但疗效不一。目前尚无循证医学支持的治疗方法可推荐。
