Department of Pharmacology, Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, China.
Front Immunol. 2023 Mar 22;14:1152312. doi: 10.3389/fimmu.2023.1152312. eCollection 2023.
Pancreatic cancer is one of the most dangerous types of cancer today, notable for its low survival rate and fibrosis. Deciphering the cellular composition and intercellular interactions in the tumor microenvironment (TME) is a necessary prerequisite to combat pancreatic cancer with precision. Cancer-associated fibroblasts (CAFs), as major producers of extracellular matrix (ECM), play a key role in tumor progression. CAFs display significant heterogeneity and perform different roles in tumor progression. Tumor cells turn CAFs into their slaves by inducing their metabolic dysregulation, exacerbating fibrosis to acquire drug resistance and immune evasion. This article reviews the impact of metabolic reprogramming, effect of obesity and cellular crosstalk of CAFs and tumor cells on fibrosis and describes relevant therapies targeting the metabolic reprogramming.
胰腺癌是当今最危险的癌症类型之一，其特点是存活率低和纤维化。解析肿瘤微环境（TME）中的细胞组成和细胞间相互作用是精准治疗胰腺癌的必要前提。癌症相关成纤维细胞（CAFs）作为细胞外基质（ECM）的主要产生者，在肿瘤进展中起着关键作用。CAFs 表现出显著的异质性，并在肿瘤进展中发挥不同的作用。肿瘤细胞通过诱导 CAFs 的代谢失调，加剧纤维化以获得耐药性和免疫逃避，将 CAFs 变成它们的奴隶。本文综述了代谢重编程对 CAFs 和肿瘤细胞代谢重编程的影响、肥胖的影响以及 CAFs 和肿瘤细胞的细胞串扰对纤维化的影响，并描述了针对代谢重编程的相关治疗方法。
