Saghir Saloua, Imenes Kristin, Schiavone Giuseppe
Department of Microsystems, Faculty of Technology, Natural Sciences and Maritime Sciences, University of South-Eastern Norway, Horten, Norway.
Front Bioeng Biotechnol. 2023 Mar 24;11:1150147. doi: 10.3389/fbioe.2023.1150147. eCollection 2023.
Recent research aiming at the development of electroceuticals for the treatment of medical conditions such as degenerative diseases, cardiac arrhythmia and chronic pain, has given rise to microfabricated implanted bioelectronic devices capable of interacting with host biological tissues in synergistic modalities. Owing to their multimodal affinity to biological tissues, hydrogels have emerged as promising interface materials for bioelectronic devices. Here, we review the state-of-the-art and forefront in the techniques used by research groups for the integration of hydrogels into the microfabrication processes of bioelectronic devices, and present the manufacturability challenges to unlock their further clinical deployment.
最近旨在开发用于治疗退行性疾病、心律失常和慢性疼痛等病症的电子药物的研究，催生了能够以协同方式与宿主生物组织相互作用的微纳加工植入式生物电子设备。由于水凝胶对生物组织具有多模态亲和力，它们已成为生物电子设备有前景的界面材料。在此，我们回顾了各研究团队将水凝胶集成到生物电子设备微纳加工过程中所使用技术的最新进展和前沿动态，并提出了实现其进一步临床应用的可制造性挑战。
