Bartlett Mabel, He Mengdi, Ranke Daniel, Wang Yingqiao, Cohen-Karni Tzahi
Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
Department of Materials Science and Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
MRS Adv. 2023 Nov;8(19):1047-1060. doi: 10.1557/s43580-023-00645-8. Epub 2023 Sep 22.
Seamless integration of the body and electronics toward the understanding, quantification, and control of disease states remains one of the grand scientific challenges of this era. As such, research efforts have been dedicated to developing bioelectronic devices for chemical, mechanical, and electrical sensing, and cellular and tissue functionality modulation. The technologies developed to achieve these capabilities cross a wide range of materials and scale (and dimensionality), e.g., from micrometer to centimeters (from 2-dimensional (2D) to 3-dimensional (3D) assemblies). The integration into multimodal systems which allow greater insight and control into intrinsically multifaceted biological systems requires careful design and selection. This will highlight the state-of-the-art in cellular recording and modulation as well as the material considerations for the design and manufacturing of devices integrating their capabilities.
将人体与电子设备无缝集成，以实现对疾病状态的理解、量化和控制，仍然是这个时代重大的科学挑战之一。因此，研究工作致力于开发用于化学、机械和电传感以及细胞和组织功能调节的生物电子设备。为实现这些功能而开发的技术跨越了广泛的材料和尺度（以及维度），例如从微米到厘米（从二维 (2D) 到三维 (3D) 组件）。集成到多模态系统中，以便对本质上多方面的生物系统有更深入的了解和控制，这需要精心设计和选择。本文将重点介绍细胞记录和调制方面的最新技术，以及集成这些功能的设备设计和制造中的材料考虑因素。
