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输尿管小细胞神经内分泌癌治疗期间PD-1抑制剂引起的心肌梗死：一例报告。

Cardiac infarction caused by PD-1 inhibitor during small cell neuroendocrine carcinoma of the ureter treatment: A case report.

作者信息

Li Xiaoying, Wen Jing, Li Hongtao, Huang Yan, Zhou Hongliang

机构信息

Department of Oncology, the People's Hospital of Yubei District of Chongqing City, Chongqing, China.

出版信息

Front Oncol. 2023 Mar 22;13:1114397. doi: 10.3389/fonc.2023.1114397. eCollection 2023.

DOI:10.3389/fonc.2023.1114397
PMID:37035192
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10073532/
Abstract

Although small cell neuroendocrine carcinoma of the ureter (ureteral SCNEC) is rare, it always leads to a poor prognosis. Also, no treatment recommendation has been given for ureteral SCNEC, with only PD-1/PD-L1 inhibitors being used for its treatment. Here, we report a case of atypical symptoms of cardiac infarction caused by a PD-1 inhibitor used in the treatment of ureteral SCNEC and hope to address concerns regarding the possible cardiac toxicity caused by PD-1/PD-L1 inhibitors in ureteral SCNEC patients.

摘要

尽管输尿管小细胞神经内分泌癌（输尿管SCNEC）很罕见，但它总是导致预后不良。此外，对于输尿管SCNEC尚未给出治疗建议，目前仅使用PD-1/PD-L1抑制剂进行治疗。在此，我们报告一例在输尿管SCNEC治疗中使用PD-1抑制剂引起的非典型心肌梗死症状的病例，并希望解决输尿管SCNEC患者中由PD-1/PD-L1抑制剂可能导致的心脏毒性问题。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f74f/10073532/98dbf8cc67e1/fonc-13-1114397-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f74f/10073532/1c8a8e9bc6aa/fonc-13-1114397-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f74f/10073532/32269f45d7cd/fonc-13-1114397-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f74f/10073532/047d202f942b/fonc-13-1114397-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f74f/10073532/b4f1f5d7b85f/fonc-13-1114397-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f74f/10073532/98dbf8cc67e1/fonc-13-1114397-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f74f/10073532/1c8a8e9bc6aa/fonc-13-1114397-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f74f/10073532/32269f45d7cd/fonc-13-1114397-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f74f/10073532/047d202f942b/fonc-13-1114397-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f74f/10073532/b4f1f5d7b85f/fonc-13-1114397-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f74f/10073532/98dbf8cc67e1/fonc-13-1114397-g005.jpg

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Cardio-onco-metabolism: metabolic remodelling in cardiovascular disease and cancer.心肿瘤代谢学：心血管疾病和癌症中的代谢重塑。
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Hyperprogression After Immunotherapy for Primary Small Cell Neuroendocrine Carcinoma of the Ureter: A Case Report.输尿管原发性小细胞神经内分泌癌免疫治疗后超进展：一例报告
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