红细胞分布宽度是乳腺癌患者的预后因素吗？一项荟萃分析。
Is red cell distribution width a prognostic factor in patients with breast cancer? A meta-analysis.
作者信息
Yin Jun-Ming, Zhu Ke-Peng, Guo Zhi-Wei, Yi Wen, He Ying, Du Guo-Cheng
机构信息
Mastothyroid Vascular Surgery, The Second Clinical Medical College of North Sichuan Medical College Nanchong Central Hospital, Nanchong, China.
出版信息
Front Surg. 2023 Mar 24;10:1000522. doi: 10.3389/fsurg.2023.1000522. eCollection 2023.
PURPOSE
The current study aimed to investigate whether red blood cell distribution width (RDW) can predict the prognosis of patients with breast cancer (BC).
METHODS
We searched four databases, including PubMed, Embase, Cochrane Library databases, and CNKI, from inception to Jun 13, 2022. The primary outcome was overall survival (OS), and the secondary outcome was disease-free survival (DFS). A subgroup analysis was conducted based on different treatments. This meta-analysis was performed with RevMan 5.3 (The Cochrane Collaboration, London, United Kingdom).
RESULTS
A total of seven studies including 4,884 BC patients were identified. The high RDW group had a larger tumor size (OR = 2.12, 95% CI = 1.67 to 2.68, < 0.01), higher proportions of advanced stage tumors (OR = 1.77, 95% CI = 1.38 to 2.27, < 0.01), more lymph node metastases (OR = 2.00, 95% CI = 1.58 to 2.51, < 0.01) and lower HER-2 expression (OR = 0.76, 95% CI = 0.61 to 0.95, = 0.02). For prognosis, after pooling all the data, we found that the high RDW group was associated with worse OS (HR = 2.12, 95% CI = 1.47 to 3.08, < 0.01) and DFS (HR = 1.77, 95% CI = 1.32 to 2.37, < 0.01). The subgroup analysis found that RDW had prognostic significance but only for surgery-only patients (HR = 2.41, 95% CI = 1.67 to 3.49, < 0.01).
CONCLUSION
High RDW was associated with worse OS and DFS. Therefore, RDW was a simple predictive factor for the prognosis of BC patients.
目的
本研究旨在调查红细胞分布宽度（RDW）是否能够预测乳腺癌（BC）患者的预后。
方法
我们检索了4个数据库，包括PubMed、Embase、Cochrane图书馆数据库和中国知网，检索时间从建库至2022年6月13日。主要结局为总生存期（OS），次要结局为无病生存期（DFS）。基于不同治疗方法进行亚组分析。使用RevMan 5.3（英国伦敦Cochrane协作网）进行本荟萃分析。
结果
共纳入7项研究，包括4884例BC患者。RDW高的组肿瘤体积更大（OR = 2.12，95%CI = 1.67至2.68，P < 0.01），晚期肿瘤比例更高（OR = 1.77，95%CI = 1.38至2.27，P < 0.01），淋巴结转移更多（OR = 2.00，95%CI = 1.58至2.51，P < 0.01），HER-2表达更低（OR = 0.76，95%CI = 0.61至0.95，P = 0.02）。对于预后，汇总所有数据后，我们发现RDW高的组OS更差（HR = 2.12，95%CI = 1.47至3.08，P < 0.01），DFS也更差（HR = 1.77，95%CI = 1.32至2.37，P < 0.01）。亚组分析发现，RDW具有预后意义，但仅对单纯手术患者有意义（HR = 2.41，95%CI = 1.67至3.49，P < 0.01）。
结论
高RDW与更差的OS和DFS相关。因此，RDW是BC患者预后的一个简单预测因素。
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