Yan Shuai, Kong Jian, Zhao Zheng-Fei, Yao Hui
Department of Gastrointestinal Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
School of Clinical Medical Sciences, Southwest Medical University, Luzhou, China.
Transl Cancer Res. 2023 Jul 31;12(7):1816-1825. doi: 10.21037/tcr-23-53. Epub 2023 Jun 28.
For cancer patients, red blood cell distribution width (RDW) is a readily accessible and cost-effective preoperative prognostic predictor. This study aimed to determine whether RDW is a predictive factor for individuals undergoing radical surgery for gastric cancer (GC).
A literature search was performed to select relevant studies for inclusion in the subsequent meta-analysis. Relevant data were pooled to assess the association between RDW and GC results, including overall survival (OS), disease-free survival (DFS), and cancer-specific survival (CSS), as well as clinicopathological features.
The meta-analysis and systemic review included data from 8 studies comprising 1,587 individuals diagnosed with GC. In this context, RDW refers to the coefficient of variation of RDW (RDW-CV). A high level of RDW-CV was significantly associated with older age [odds ratio (OR) =2.25; 95% confidence interval (CI): 1.72-2.94; P<0.00001], larger tumor diameter (OR =1.90; 95% CI: 1.42-2.56; P<0.0001), and vascular invasion (OR =2.22; 95% CI: 1.10-4.49; P=0.03). After hazard ratios (HRs) and 95% CIs were pooled, RDW-CV was found to be an independent prognostic factor of OS (HR =1.79; 95% CI: 1.21-2.66; I=85%; P=0.004), DFS (HR =1.81; 95% CI: 1.37-2.39; I=0%; P<0.0001), and CSS (HR =2.73; 95% CI: 1.36-5.49; I=0%; P=0.005) in patients with GC.
The association between high levels of RDW-CV and poor survival in GC suggests that RDW-CV may be a viable prognostic indicator for patients with GC.
对于癌症患者，红细胞分布宽度（RDW）是一种易于获取且经济高效的术前预后预测指标。本研究旨在确定RDW是否为接受胃癌（GC）根治性手术患者的预测因素。
进行文献检索以选择相关研究纳入后续的荟萃分析。汇总相关数据以评估RDW与GC结果之间的关联，包括总生存期（OS）、无病生存期（DFS）和癌症特异性生存期（CSS），以及临床病理特征。
荟萃分析和系统评价纳入了8项研究的数据，共1587例诊断为GC的患者。在此背景下，RDW指的是RDW的变异系数（RDW-CV）。高水平的RDW-CV与高龄显著相关[比值比（OR）=2.25；95%置信区间（CI）：1.72-2.94；P<0.00001]、肿瘤直径较大（OR =1.90；95%CI：1.42-2.56；P<0.0001）和血管侵犯（OR =2.22；95%CI：1.10-4.49；P=0.03）。汇总风险比（HR）和95%CI后，发现RDW-CV是GC患者OS（HR =1.79；95%CI：1.21-2.66；I=85%；P=0.004）、DFS（HR =1.81；95%CI：1.37-2.39；I=0%；P<0.0001）和CSS（HR =2.73；95%CI：1.36-5.49；I=0%；P=0.005）的独立预后因素。
GC患者中高水平的RDW-CV与不良生存之间的关联表明，RDW-CV可能是GC患者可行的预后指标。
