新型N(SCF)(CF) -胺类：合成、可扩展性及稳定性
Novel N(SCF)(CF)-amines: synthesis, scalability and stability.
作者信息
Yang Yi, Saffon-Merceron Nathalie, Vantourout Julien C, Tlili Anis
机构信息
Institute of Chemistry and Biochemistry (ICBMS-UMR CNRS 5246), Univ Lyon, Université Lyon 1, CNRS, CPE-Lyon, INSA 43 Bd du 11 Novembre 1918 69622 Villeurbanne France
Institut de Chimie de Toulouse (FR 2599), Université de Toulouse, CNRS 118 Route de Narbonne 31062 Toulouse France.
出版信息
Chem Sci. 2023 Mar 13;14(14):3893-3898. doi: 10.1039/d2sc06542h. eCollection 2023 Apr 5.
We disclosed herein a straightforward strategy for the synthesis of unprecedented -((trifluoromethyl)thio), -(trifluoromethyl) amines using a combination of isothiocyanates with a fluoride source and an electrophilic trifluoromethylthiolation reagent. More interestingly, the scalability of the methodology has been demonstrated and the stability of the new motif has been studied.
我们在此公开了一种直接的策略，用于使用异硫氰酸酯与氟源和亲电三氟甲硫基化试剂的组合来合成前所未有的-((三氟甲基)硫基), -(三氟甲基)胺。更有趣的是，该方法的可扩展性已得到证明，并且对新基序的稳定性进行了研究。
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