UMR 8076, BioCIS, Univ. Paris-Sud, CNRS, Université Paris-Saclay, 92290 Châtenay-Malabry, France.
Université Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles, 91198 Gif-sur-Yvette, France.
Chem Commun (Camb). 2021 Oct 7;57(80):10351-10354. doi: 10.1039/d1cc04538e.
We report here the synthesis of a novel family of -CF hydrazines from a direct way involving the available and cheap Langlois reagent (CFSONa). These derivatives have shown very high stability whatever the conditions used and are excellent precursors for building previously inaccessible -CF functionalized compounds, such as substituted hydrazides, hydrazine-amino-acids, hydrazones, -aziridines and pyrazoles.
我们在这里报告了一种新型 -CF 腙的合成方法，该方法直接涉及到可用且廉价的朗格洛伊斯试剂（CFSONa）。这些衍生物表现出非常高的稳定性，无论使用何种条件，并且是构建以前无法获得的 -CF 官能化化合物的优异前体，例如取代的酰肼、肼基氨基酸、腙、氮丙啶和吡唑。
