Rosenfeld Manuela, Nickel Katie, Ladiges Warren
Department of Comparative Medicine, School of Medicine, University of Washington, Seattle, WA, USA.
Aging Pathobiol Ther. 2023;5(1):33-35. doi: 10.31491/apt.2023.03.109. Epub 2023 Mar 29.
Sleep deprivation is known to cause memory impairment and is associated with inflammation and cell damage linked to neurodegenerative diseases. GHK (glycyl-L-histidyl-L-lysine) is a naturally occurring tripeptide found in mammalian plasma. GHK has anti-inflammatory activity and can pass through the blood-brain barrier suggesting the potential to prevent neuroinflammation associated with sleep deprivation. In this study, mice were injected with 15 mg/kg GHK per day for five days and sleep deprived on the last two days of treatment. Sleep-deprived mice treated with GHK did not show the acute learning impairment seen in sleep-deprived mice treated with saline. GHK prevented an increase in MCP-1 and nitrotyrosine levels in the hippocampus of sleep-deprived mice suggesting that inflammatory and reactive nitrogen/oxygen species activity could be therapeutic targets for learning impairment associated with short-term sleep deprivation.
众所周知，睡眠剥夺会导致记忆障碍，并与炎症以及与神经退行性疾病相关的细胞损伤有关。甘氨酰-L-组氨酰-L-赖氨酸（GHK）是一种存在于哺乳动物血浆中的天然三肽。GHK具有抗炎活性，并且能够穿过血脑屏障，这表明它具有预防与睡眠剥夺相关的神经炎症的潜力。在本研究中，小鼠每天注射15毫克/千克GHK，持续五天，并在治疗的最后两天进行睡眠剥夺。用GHK治疗的睡眠剥夺小鼠并未表现出在用生理盐水治疗的睡眠剥夺小鼠中所见到的急性学习障碍。GHK可防止睡眠剥夺小鼠海马中单核细胞趋化蛋白-1（MCP-1）和硝基酪氨酸水平的升高，这表明炎症以及活性氮/氧物质的活性可能是与短期睡眠剥夺相关的学习障碍的治疗靶点。
