D'Ercole A J, Hill D J, Strain A J, Underwood L E
Pediatr Res. 1986 Mar;20(3):253-5. doi: 10.1203/00006450-198603000-00011.
To investigate the possible role of somatomedin-C/insulin-like growth factor I (Sm-C/IGF I) in early human development, we measured this peptide by radioimmunoassay in extracts of multiple tissues and in plasma from fetuses during the first half of gestation (9-19 wk). All tissues contained Sm-C/IGF I far in excess of that which could be accounted for by Sm-C/IGF I derived from blood entrapment. Lung and intestine had the highest concentrations (166 +/- 35 mU/g, n = 25 and 160 +/- 20 mU/g, n = 19, respectively; mean +/- SEM) and liver the lowest (67 +/- 16 mU/g, n = 26). Plasma concentrations were 270 +/- 20 mU/ml (n = 20). Neither fetal weight (6-258 g) nor gestational age correlated with Sm-C/IGF I concentrations in any tissue or in plasma. These findings suggest that Sm-C/IGF I is synthesized in many human fetal tissues from as early as the 1st trimester. They also provide further evidence for an autocrine/paracrine role of this peptide growth factor.
为研究生长调节素-C/胰岛素样生长因子I（Sm-C/IGF I）在人类早期发育中的可能作用，我们采用放射免疫分析法测定了妊娠前半期（9 - 19周）胎儿多种组织提取物及血浆中的这种肽。所有组织中Sm-C/IGF I的含量远远超过因血液滞留而产生的Sm-C/IGF I含量。肺和肠中的浓度最高（分别为166±35 mU/g，n = 25和160±20 mU/g，n = 19；均值±标准误），肝脏中的浓度最低（67±16 mU/g, n = 26）。血浆浓度为270±20 mU/ml（n = 20）。胎儿体重（6 - 258 g）和胎龄均与任何组织或血浆中的Sm-C/IGF I浓度无关。这些发现表明，Sm-C/IGF I早在妊娠早期就在许多人类胎儿组织中合成。它们还为这种肽生长因子的自分泌/旁分泌作用提供了进一步的证据。
