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儿科和青少年癌症患者生育力保存的当前问题。

Current Issues in Fertility Preservation Among Pediatric and Adolescent Cancer Patients.

机构信息

Children's National Medical Center, Center for Cancer and Blood Disorders, 111 Michigan Avenue NW, Room W4-604, Washington, D.C., 20010, USA.

出版信息

Curr Oncol Rep. 2023 Jul;25(7):793-802. doi: 10.1007/s11912-023-01401-9. Epub 2023 Apr 10.

Abstract

PURPOSE OF REVIEW

Although fertility preservation is not yet fully integrated into the comprehensive cancer care of pediatric and adolescent patients, advances continue to take place. This review summarizes recent updates and trends for health care professionals caring for these patients.

RECENT FINDINGS

The creation of standardized infertility risk assessment guidelines offers the opportunity to provide greater consistency in clinical care and to provide a current baseline for future research studies seeking to refine risk stratification for individual patients. New agents are being introduced into cancer care; as their use increases, information about their impact on fertility is being studied. Ovarian tissue cryopreservation offers a new standard of care option for fertility preservation, but additional studies are needed to further assess efficacy and impact on ovarian reserve among pediatric and adolescent patients. Standardization of fertility preservation recommendations among certain sub-populations may also make it easier to provide greater consistency in clinical care. Advances continue to be made in the field of fertility preservation, but dissemination of this information is critical to moving toward fertility preservation truly being a part of comprehensive cancer care.

摘要

目的综述

尽管生育力保护尚未完全纳入儿科和青少年癌症患者的综合治疗中,但仍在不断取得进展。本文综述了为这些患者提供医疗服务的专业人员最近更新和关注的趋势。

最近的发现

制定标准化的生育力风险评估指南为提供更一致的临床护理提供了机会,并为未来寻求个体化患者风险分层的研究提供了当前的基线。新的药物正被引入癌症治疗中;随着其使用的增加,关于其对生育力影响的信息正在被研究。卵巢组织冷冻保存为生育力保护提供了新的标准治疗选择,但仍需要进一步的研究来进一步评估其在儿科和青少年患者中的疗效和对卵巢储备的影响。在某些亚人群中对生育力保护建议进行标准化也可以使临床护理更加一致。生育力保护领域不断取得进展,但传播这些信息对于将生育力保护真正纳入综合癌症治疗中至关重要。

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