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The race is on: bispecifics vs CAR T cells in B-cell lymphoma.

作者信息

Gurumurthi Ashwath, Westin Jason, Subklewe Marion

机构信息

Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX.

Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany.

出版信息

Blood Adv. 2023 Oct 10;7(19):5713-5716. doi: 10.1182/bloodadvances.2022009066.

DOI:10.1182/bloodadvances.2022009066
PMID:37037004
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10539863/
Abstract
摘要

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N Engl J Med. 2022 Dec 15;387(24):2220-2231. doi: 10.1056/NEJMoa2206913. Epub 2022 Dec 11.
2
A real-world comparison of tisagenlecleucel and axicabtagene ciloleucel CAR T cells in relapsed or refractory diffuse large B cell lymphoma.Tisagenlecleucel 和 axicabtagene ciloleucel CAR T 细胞治疗复发或难治性弥漫性大 B 细胞淋巴瘤的真实世界比较。
Nat Med. 2022 Oct;28(10):2145-2154. doi: 10.1038/s41591-022-01969-y. Epub 2022 Sep 22.
3
Role of Bispecific Antibodies in Relapsed/Refractory Diffuse Large B-Cell Lymphoma in the CART Era.双特异性抗体在 CAR-T 时代复发/难治性弥漫性大 B 细胞淋巴瘤中的作用。
Front Immunol. 2022 Jul 19;13:909008. doi: 10.3389/fimmu.2022.909008. eCollection 2022.
4
Patterns of Use, Outcomes, and Resource Utilization among Recipients of Commercial Axicabtagene Ciloleucel and Tisagenlecleucel for Relapsed/Refractory Aggressive B Cell Lymphomas.商业用 axicabtagene ciloleucel 和 tisagenlecleucel 治疗复发/难治性侵袭性 B 细胞淋巴瘤患者的使用模式、结局和资源利用。
Transplant Cell Ther. 2022 Oct;28(10):669-676. doi: 10.1016/j.jtct.2022.07.011. Epub 2022 Jul 16.
5
Safety and efficacy of mosunetuzumab, a bispecific antibody, in patients with relapsed or refractory follicular lymphoma: a single-arm, multicentre, phase 2 study.在复发或难治性滤泡淋巴瘤患者中,双特异性抗体 mosunetuzumab 的安全性和疗效:一项单臂、多中心、2 期研究。
Lancet Oncol. 2022 Aug;23(8):1055-1065. doi: 10.1016/S1470-2045(22)00335-7. Epub 2022 Jul 5.
6
Axicabtagene ciloleucel compared to tisagenlecleucel for the treatment of aggressive B-cell lymphoma.阿基仑赛与 tisagenlecleucel 治疗侵袭性 B 细胞淋巴瘤的比较。
Haematologica. 2023 Jan 1;108(1):110-121. doi: 10.3324/haematol.2022.280805.
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Lisocabtagene maraleucel versus standard of care with salvage chemotherapy followed by autologous stem cell transplantation as second-line treatment in patients with relapsed or refractory large B-cell lymphoma (TRANSFORM): results from an interim analysis of an open-label, randomised, phase 3 trial.西达基奥仑赛对比挽救化疗后自体干细胞移植作为二线治疗复发或难治性大 B 细胞淋巴瘤患者的标准治疗(TRANSFORM):一项开放标签、随机、3 期临床试验的中期分析结果。
Lancet. 2022 Jun 18;399(10343):2294-2308. doi: 10.1016/S0140-6736(22)00662-6.
8
A national service for delivering CD19 CAR-Tin large B-cell lymphoma - The UK real-world experience.用于递送 CD19 CAR-T 细胞治疗大 B 细胞淋巴瘤的国家服务 - 英国真实世界经验。
Br J Haematol. 2022 Aug;198(3):492-502. doi: 10.1111/bjh.18209. Epub 2022 Apr 29.
9
Odronextamab, a human CD20×CD3 bispecific antibody in patients with CD20-positive B-cell malignancies (ELM-1): results from the relapsed or refractory non-Hodgkin lymphoma cohort in a single-arm, multicentre, phase 1 trial.奥德罗内昔单抗,一种针对 CD20 阳性 B 细胞恶性肿瘤的人源 CD20×CD3 双特异性抗体(ELM-1):在一项单臂、多中心、1 期临床试验中,复发或难治性非霍奇金淋巴瘤队列的结果。
Lancet Haematol. 2022 May;9(5):e327-e339. doi: 10.1016/S2352-3026(22)00072-2. Epub 2022 Apr 1.
10
GLA/DRST real-world outcome analysis of CAR T-cell therapies for large B-cell lymphoma in Germany.德国 GLA/DRST 真实世界研究分析嵌合抗原受体 T 细胞疗法治疗大 B 细胞淋巴瘤的结果。
Blood. 2022 Jul 28;140(4):349-358. doi: 10.1182/blood.2021015209.