Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.
Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China; Clinical Research Center, Shengjing Hospital of China Medical University, Shenyang, China.
Ecotoxicol Environ Saf. 2023 May;256:114877. doi: 10.1016/j.ecoenv.2023.114877. Epub 2023 Apr 8.
Recent evidence advises particles with a diameter of 2.5 µm or less (PM) might be a prognostic factor for ovarian cancer (OC) survival. The oxidative balance score (OBS) incorporates diet-lifestyle factors to estimate individuals' anti-oxidant exposure status which may be relevant to cancer prognosis. We aimed to investigate the roles of PM, and OBS and their interaction in OC prognosis. 663 patients with OC were enrolled in the current study. Satellite-derived annual average exposures to PM based on patients' residential locations. The OBS was calculated based on 16 different diet-lifestyle components derived using an acknowledged self-reported questionnaire. The Cox regression model was performed to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for overall survival (OS). We also assessed the effect of modification between PM and OS by OBS via interaction terms. During a median follow-up of 37.57 (interquartile:35.27-40.17) months, 123 patients died. Compared to low-concentration PM exposure, high PM during 1 year before diagnosis was associated with worse OC survival (HR= 1.19, 95% CI = 1.01-1.42). We observed an improved OS with the highest compared with the lowest OBS (HR = 0.46, 95% CI = 0.27-0.79, P for trend < 0.05). Notably, we also found an additive interaction between low OBS and high exposure to PM, with the corresponding associations of PM being more pronounced among participants with lower OBS (HR = 1.42, 95% CI = 1.09-1.86). PM may blunt OC survival, but high OBS represented an antioxidative performance that could alleviate the adverse association of PM and OS.
最近的证据表明，直径为 2.5 µm 或更小的颗粒（PM）可能是卵巢癌（OC）生存的预后因素。氧化平衡评分（OBS）结合饮食-生活方式因素，估计个体的抗氧化暴露状态，这可能与癌症预后相关。我们旨在研究 PM 及其与 OC 预后的相互作用的作用。本研究纳入了 663 名 OC 患者。根据患者的居住地点，利用卫星获得的 PM 年平均暴露量。OBS 是根据 16 种不同的饮食-生活方式成分计算得出的，这些成分是使用公认的自我报告问卷得出的。采用 Cox 回归模型估计总生存期（OS）的风险比（HR）和 95%置信区间（CI）。我们还通过交互项评估了 PM 和 OS 之间的修饰作用对 OBS 的影响。在中位随访 37.57 个月（四分位距：35.27-40.17）期间，有 123 名患者死亡。与低浓度 PM 暴露相比，诊断前 1 年高 PM 暴露与 OC 生存较差相关（HR=1.19，95%CI=1.01-1.42）。与最低 OBS 相比，我们观察到最高 OBS 与改善的 OS 相关（HR=0.46，95%CI=0.27-0.79，P<0.05）。值得注意的是，我们还发现低 OBS 和高 PM 暴露之间存在附加交互作用，在 OBS 较低的参与者中，PM 的相关性更为明显（HR=1.42，95%CI=1.09-1.86）。PM 可能会削弱 OC 的生存能力，但高 OBS 代表了一种抗氧化性能，可以减轻 PM 与 OS 之间的不利关联。
