核酸免疫治疗和疫苗：胶质母细胞瘤多形性治疗的一种有前途的方法。
Nucleic acid immunotherapeutics and vaccines: A promising approach to glioblastoma multiforme treatment.
机构信息
Department of Pharmaceutics and Center for Pharmaceutical Engineering and Sciences, Institute for Structural Biology and Drug Discovery, School of Pharmacy; The Developmental Therapeutics Program, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.
Department of Pharmaceutics and Center for Pharmaceutical Engineering and Sciences, Institute for Structural Biology and Drug Discovery, School of Pharmacy; The Developmental Therapeutics Program, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA; Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.
出版信息
Int J Pharm. 2023 May 10;638:122924. doi: 10.1016/j.ijpharm.2023.122924. Epub 2023 Apr 8.
Glioblastoma multiforme (GBM) is a deadly and difficult to treat primary brain tumor for which satisfactory therapeutics have yet to be discovered. While cancer immunotherapeutics, such as immune checkpoint inhibitors, have successfully improved the treatment of some other types of cancer, the poorly immunogenic GBM tumor cells and the immunosuppressive GBM tumor microenvironment have made it difficult to develop GBM immunotherapeutics. Nucleic acids therapeutics and vaccines, particularly those of mRNA, have become a popular field of research in recent years. This review presents the progress of nucleic acid therapeutics and vaccines for GBM and briefly covers some representative delivery methods of nucleic acids to the central nervous system (CNS) for GBM therapy.
多形性胶质母细胞瘤（GBM）是一种致命且难以治疗的原发性脑肿瘤，目前尚未发现令人满意的治疗方法。虽然癌症免疫疗法，如免疫检查点抑制剂，已成功改善了一些其他类型癌症的治疗效果，但 GBM 肿瘤细胞的免疫原性差和 GBM 肿瘤微环境使得开发 GBM 免疫疗法变得困难。核酸疗法和疫苗，特别是 mRNA 疫苗，近年来成为研究的热门领域。本文综述了 GBM 的核酸治疗和疫苗的研究进展，并简要介绍了一些用于 GBM 治疗的代表性中枢神经系统（CNS）核酸递药方法。
Zotero 插件