Kolko Miriam, Mouhammad Zaynab Ahmad, Cvenkel Barbara
Department of Drug Design and Pharmacology, University of Copenhagen, Denmark; Department of Ophthalmology, Copenhagen University Hospital, Rigshospitalet, Glostrup, Denmark.
Department of Drug Design and Pharmacology, University of Copenhagen, Denmark.
Pharmacol Ther. 2023 May;245:108412. doi: 10.1016/j.pharmthera.2023.108412. Epub 2023 Apr 8.
Glaucoma is characterized by a continuous loss of retinal ganglion cells. The cause of glaucoma is associated with an increase in intraocular pressure (IOP), but the underlying pathophysiology is diverse and, in most cases, unknown. There is an indisputable unmet need to identify new pathways involved in glaucoma pathogenesis. Increasing evidence suggests that bioactive lipids may be critical in the development and progression of glaucoma. Preclinical and clinical bioactive lipid targets exist and are being developed. In this review, we aim to shed light on the potential of bioactive lipids for the prevention, diagnosis, prognosis, and treatment of glaucoma by asking the question "is fat the future for saving sight".
青光眼的特征是视网膜神经节细胞持续丢失。青光眼的病因与眼内压（IOP）升高有关，但其潜在的病理生理学是多样的，并且在大多数情况下尚不清楚。确定青光眼发病机制中涉及的新途径存在无可争议的未满足需求。越来越多的证据表明，生物活性脂质可能在青光眼的发生和发展中起关键作用。临床前和临床生物活性脂质靶点已经存在并且正在开发中。在本综述中，我们旨在通过提出“脂肪会是拯救视力的未来吗”这个问题，来阐明生物活性脂质在青光眼预防、诊断、预后和治疗方面的潜力。
