乳腺癌休眠。
Dormancy in Breast Cancer.
机构信息
Division of Hematology and Oncology, Department of Medicine and Department of Otolaryngology, Department of Oncological Sciences, Black Family Stem Cell Institute, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Department of Cancer Biology and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
出版信息
Cold Spring Harb Perspect Med. 2023 Nov 1;13(11):a041331. doi: 10.1101/cshperspect.a041331.
The pattern of delayed recurrence in a subset of breast cancer patients has long been explained by a model that incorporates a variable period of cellular or tumor mass dormancy prior to disease relapse. In this review, we critically evaluate existing data to develop a framework for inferring the existence of dormancy in clinical contexts of breast cancer. We integrate these clinical data with rapidly evolving mechanistic insights into breast cancer dormancy derived from a broad array of genetically engineered mouse models as well as experimental models of metastasis. Finally, we propose actionable interventions and discuss ongoing clinical trials that translate the wealth of knowledge gained in the laboratory to the long-term clinical management of patients at a high risk of developing recurrence.
长期以来，一部分乳腺癌患者复发延迟的模式可以用一种模型来解释，该模型包括在疾病复发前存在一个细胞或肿瘤休眠的可变期。在这篇综述中，我们批判性地评估了现有数据，以建立一个在乳腺癌临床背景下推断休眠存在的框架。我们将这些临床数据与从广泛的基因工程小鼠模型以及转移的实验模型中获得的对乳腺癌休眠的快速发展的机制见解相结合。最后，我们提出了可行的干预措施，并讨论了正在进行的临床试验，这些试验将实验室获得的丰富知识转化为对有高复发风险的患者的长期临床管理。
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