Ehrich M, Briles R W, Briles W E, Dunnington E A, Martin A, Siegel P B, Gross W B
Poult Sci. 1986 Feb;65(2):375-9. doi: 10.3382/ps.0650375.
Indices of acute and delayed toxicity following administration of triorthotolyl phosphate (TOTP) were measured in roosters from lines of chickens originating from the Cornell randombred population. Matings were designed to produce individuals that had presence or absence of allele 21 of the B blood system. Non-B21 individuals had allele 13 or 31. Acute inhibition of esterases (neurotoxic esterase, liver cholinesterase, plasma cholinesterases, and plasma carboxylesterases) occurred in all birds within 24 hr of a single oral dose of 360 mg/kg TOTP. Clinical signs of delayed neuropathy were evident within 12 days of TOTP administration, with no significant difference between genotypes. Dietary deoxycorticosterone (40 to 200 ppm) appeared incapable of statistically significant modification of the strong effects of TOTP. Activities of blood esterases were different between roosters having B21/B21 and those with B13 and/or B31.
对来自康奈尔随机交配群体品系的公鸡，测定了给予磷酸三邻甲苯酯（TOTP）后的急性和迟发性毒性指标。交配设计旨在产生具有或不具有B血型系统等位基因21的个体。非B21个体具有等位基因13或31。单次口服剂量为360mg/kg TOTP后，所有鸟类在24小时内均出现酯酶（神经毒性酯酶、肝脏胆碱酯酶、血浆胆碱酯酶和血浆羧酸酯酶）的急性抑制。给予TOTP后12天内，迟发性神经病变的临床症状明显，不同基因型之间无显著差异。日粮脱氧皮质酮（40至200ppm）似乎无法对TOTP的强烈作用进行统计学上的显著改变。具有B21/B21的公鸡与具有B13和/或B31的公鸡之间，血液酯酶活性不同。
