Suppr超能文献

口服表达人乙醇脱氢酶的益生菌可减轻小鼠急性酒精摄入引起的损伤。

Oral Probiotic Expressing Human Ethanol Dehydrogenase Attenuates Damage Caused by Acute Alcohol Consumption in Mice.

机构信息

Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.

University of the Chinese Academy of Sciences, Beijing, China.

出版信息

Microbiol Spectr. 2023 Jun 15;11(3):e0429422. doi: 10.1128/spectrum.04294-22. Epub 2023 Apr 11.

Abstract

Alcohol is an essential drug in human life with multiple medical functions, but excessive alcohol intake, even a single episode of binge drinking, can cause serious damage. Reducing alcohol consumption or absorption is a direct way to alleviate the related harm. Alcohol is decomposed successively by alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) in the liver. Here, we produced a human ADH1B (hADH1B)-expressing probiotic, a recombinant Lactococcus lactis, that aimed to enhance alcohol degradation in the intestinal tract after oral administration. Our results showed that the oral hADH1B-expressing probiotic reduced alcohol absorption, prolonged the alcohol tolerance time, and shortened the recovery time after acute alcohol challenge. More importantly, the liver and intestine were protected from acute injury caused by alcohol challenge. Therefore, the engineered probiotic has the potential to protect organ damage from alcohol consumption. Furthermore, this engineered probiotic may have beneficial effects on alcohol-related diseases such as alcoholic fatty liver disease. Alcohol plays an important role in medical treatment, culture, and social interaction. However, excessive alcohol consumption or improper alcohol intake patterns can lead to serious damage to health. Aiming to reduce the harm of alcohol consumption, we designed a recombinant probiotic expressing hADH1B. Our results showed that this recombinant probiotic can reduce alcohol absorption and protect the body from alcohol damage, including hangover, liver, and intestinal damage. Reducing alcohol damage is helpful to the health of people with difficulty in abstinence. The engineered probiotic may provide new strategies for treatment and prevention of the negative effects of alcohol, and it also has the potential for widespread application.

摘要

酒精是人类生活中必不可少的药物,具有多种医学功能,但过量饮酒,甚至单次狂饮,都会造成严重的损害。减少酒精的摄入或吸收是缓解相关伤害的直接方法。酒精在肝脏中先后被乙醇脱氢酶(ADH)和乙醛脱氢酶(ALDH)分解。在这里,我们生产了一种人源 ADH1B(hADH1B)表达的益生菌,即重组乳球菌 lactis,旨在增强口服后在肠道中降解酒精的能力。我们的结果表明,口服 hADH1B 表达的益生菌减少了酒精的吸收,延长了酒精耐受时间,并缩短了急性酒精挑战后的恢复时间。更重要的是,益生菌保护了肝脏和肠道免受急性酒精损伤。因此,该工程益生菌具有保护器官免受酒精消耗引起的损伤的潜力。此外,该工程益生菌可能对酒精性脂肪肝等与酒精相关的疾病有有益的影响。

酒精在医疗、文化和社会交往中起着重要作用。然而,过量饮酒或不当的饮酒模式会导致严重的健康损害。为了减少饮酒的危害,我们设计了表达 hADH1B 的重组益生菌。我们的结果表明,这种重组益生菌可以减少酒精的吸收,保护身体免受酒精的伤害,包括宿醉、肝脏和肠道损伤。减少酒精的损害有助于那些难以戒酒的人的健康。该工程益生菌可能为治疗和预防酒精的负面影响提供新的策略,也具有广泛的应用潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c98/10269551/080130a07104/spectrum.04294-22-f001.jpg

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验