癌症的暗物质：照亮深渊揭示新疗法的宇宙。
Cancer's Dark Matter: Lighting the Abyss Unveils Universe of New Therapies.
机构信息
Robert W. Franz Cancer Center, Earle A. Chiles Research Institute, Providence Cancer Institute, Providence Portland Medical Center, Portland, Oregon.
Department of Molecular Microbiology and Immunology, and Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon.
出版信息
Clin Cancer Res. 2023 Jun 13;29(12):2173-2175. doi: 10.1158/1078-0432.CCR-23-0422.
The authors of a recent study identified noncanonical peptides (NCP) presented by cancer cells' HLA and observed lack of reactivity to these antigens by endogenous tumor-reactive T cells. In vitro sensitization generated NCP-reactive T cells that recognized epitopes shared by a majority of cancers tested, providing opportunities for novel therapies to shared antigens. See related article by Lozano-Rabella et al., p. 2250.
最近一项研究的作者鉴定了由癌细胞 HLA 呈递的非典型肽（NCP），并观察到内源性肿瘤反应性 T 细胞对这些抗原无反应性。体外致敏产生了 NCP 反应性 T 细胞，这些细胞识别了大多数测试癌症共有的表位，为针对共享抗原的新疗法提供了机会。见 Lozano-Rabella 等人的相关文章，第 2250 页。
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