Division of Biomedical Engineering, Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, 14395-1561, Iran.
Department of Physical Chemistry and Technology of Polymers, Silesian University of Technology, Gliwice, Poland.
Soft Matter. 2023 May 3;19(17):3147-3161. doi: 10.1039/d2sm01084d.
Applying hydrophilic coatings on polymeric nanofibers combined with layered double hydroxide (LDH) not only enhances the efficiency of drug delivery systems but also increases cell adhesion. This work aimed to prepare poly(vinyl alcohol)/sodium alginate (PVA/SA) (2/1)-coated poly(lactic acid) (PLA) nanofibers containing curcumin-loaded layered double hydroxide (LDH) and to investigate their drug release and mechanical properties and their biocompatibility. The optimum PLA nanofibrous sample was considered to be that based on 3 wt% of curcumin-loaded LDH (PLA-3%LDH) with a drug encapsulation efficiency of ∼18% in which a minimum average nanofiber diameter of ∼476 nm along with a high tensile strength of 3.00 MPa were obtained. In the next step, a PVA/SA (2/1) layer was coated on the PLA-3%LDH; as a result, the hydrophilicity of the sample was improved and the elongation at break was decreased remarkably. In this regard the cell viability reached 80% for the coated PLA. Moreover, the formation of a layer of (PVA/SA) on the PLA nanofibers lowered the burst release and resulted in a more sustained drug release, which is a vital feature in dermal applications. A multiscale modeling method was applied for simulation of the mechanical properties of the composite scaffold and the results showed that this method can predict the data with 83% accuracy. The results of this study indicate that the formation of a layer of PVA/SA (2/1) has a significant effect on hydrophilicity and consequently improves cell adhesion and proliferation.
将亲水性涂层应用于聚合物纳米纤维并结合层状双氢氧化物（LDH）不仅可以提高药物输送系统的效率，还可以增加细胞黏附性。本工作旨在制备载姜黄素的层状双氢氧化物（LDH）负载的聚（乳酸）（PLA）纳米纤维，该纤维含有聚（乙烯醇）/海藻酸钠（PVA/SA）（2/1）涂层，并研究其药物释放、力学性能和生物相容性。认为载姜黄素 LDH 含量为 3wt%的 PLA 纳米纤维（PLA-3%LDH）为最佳 PLA 纳米纤维样条，其药物包封效率约为 18%，平均纳米纤维直径最小约为 476nm，拉伸强度为 3.00MPa。下一步，在 PLA-3%LDH 上涂覆一层 PVA/SA（2/1），从而提高了样品的亲水性，显著降低了断裂伸长率。在这种情况下，涂层 PLA 的细胞活力达到 80%。此外，在 PLA 纳米纤维上形成一层（PVA/SA）降低了突释释放，导致药物释放更持续，这是在皮肤应用中的一个重要特征。采用多尺度建模方法模拟复合支架的力学性能，结果表明该方法可以以 83%的准确率预测数据。本研究结果表明，形成一层 PVA/SA（2/1）对亲水性有显著影响，从而提高了细胞黏附和增殖。
