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Front Cell Infect Microbiol. 2022 Sep 20;12:962059. doi: 10.3389/fcimb.2022.962059. eCollection 2022.
2
Severe Mycobacterial Immune Reconstitution Inflammatory Syndrome (IRIS) in Advanced Human Immunodeficiency Virus (HIV) Has Features of Hemophagocytic Lymphohistiocytosis and Requires Prolonged Immune Suppression.严重分枝杆菌免疫重建炎症综合征（IRIS）在晚期人类免疫缺陷病毒（HIV）中具有噬血细胞性淋巴组织细胞增生症的特征，需要长期免疫抑制治疗。
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Persistent Oxidative Stress and Inflammasome Activation in CD14CD16 Monocytes From COVID-19 Patients.新冠肺炎患者 CD14+CD16+单核细胞中持续的氧化应激和炎性体激活。
Front Immunol. 2022 Jan 14;12:799558. doi: 10.3389/fimmu.2021.799558. eCollection 2021.
4
Interleukin-18 and cytotoxic impairment are independent and synergistic causes of murine virus-induced hyperinflammation.白细胞介素-18 和细胞毒性损伤是导致鼠类病毒引起的过度炎症的独立和协同原因。
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BMC Infect Dis. 2020 Jan 20;20(1):59. doi: 10.1186/s12879-020-4786-5.
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Human Inborn Errors of Immunity: 2019 Update on the Classification from the International Union of Immunological Societies Expert Committee.人类先天性免疫缺陷：国际免疫学联盟专家委员会 2019 年分类更新。
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HIV 相关分枝杆菌免疫重建炎症综合征与噬血细胞性淋巴组织细胞增生症相关基因的蛋白改变变异有关。

Mycobacterial Immune Reconstitution Inflammatory Syndrome in HIV is Associated With Protein-Altering Variants in Hemophagocytic Lymphohistiocytosis-Related Genes.

机构信息

National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

Clinical Research Directorate, Frederick National Laboratory for Cancer Research, Bethesda, Maryland, USA.

出版信息

J Infect Dis. 2023 Jul 14;228(2):111-115. doi: 10.1093/infdis/jiad059.

DOI:10.1093/infdis/jiad059
PMID:37040388
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10345459/
Abstract

People with HIV (PWH) and mycobacterial infections can develop immune reconstitution inflammatory syndrome (IRIS) after starting antiretroviral therapy. The pathophysiology of mycobacterial-IRIS overlaps with primary hemophagocytic lymphohistiocytosis (pHLH). To assess possible genetic predisposition to IRIS, protein-altering variants in genes associated with HLH were evaluated in 82 PWH and mycobacterial infections who developed IRIS (n = 56) or did not develop IRIS (n = 26). Protein-altering variants in cytotoxicity genes were found in 23.2% of IRIS patients compared to only 3.8% of those without IRIS. These findings suggest a possible genetic component in the risk of mycobacterial IRIS in PWH. Clinical Trials Registration. NCT00286767, NCT02147405.

摘要

HIV（人免疫缺陷病毒）感染者和分枝杆菌感染者在开始抗逆转录病毒治疗后可能会发展为免疫重建炎症综合征（IRIS）。分枝杆菌-IRIS 的病理生理学与原发性噬血细胞性淋巴组织细胞增生症（pHLH）重叠。为了评估 IRIS 可能的遗传易感性，评估了 82 名发生 IRIS（n = 56）或未发生 IRIS（n = 26）的 HIV 感染者和分枝杆菌感染者中与 HLH 相关的基因中的蛋白改变变异体。与未发生 IRIS 的患者相比，IRIS 患者中有 23.2%的细胞毒性基因发生了蛋白改变变异体，而只有 3.8%的患者未发生 IRIS。这些发现表明 HIV 感染者中分枝杆菌 IRIS 的风险可能存在遗传因素。临床试验注册。NCT00286767，NCT02147405。