Metivier H, Bourges J, Fritsch P, Nolibe D, Masse R
Radiat Res. 1986 May;106(2):190-200.
Absorption and retention of neptunium were determined in baboons after intragastric administration of neptunium nitrate solutions at pH 1. The effects of mass, diet, and fasting on absorption were studied. At higher mass levels (400-800 micrograms Np/kg), absorption was about 1%; at lower mass intakes (0.0009-0.005 micrograms Np/kg), absorption was reduced by 10- to 20-fold. The addition of an oxidizing agent (Fe3+) increased gastrointestinal absorption and supported the hypothesis of a reduction of Np (V) when loss masses were ingested. Diets depleted of or enriched with hydroxy acids did not modify retention of neptunium but increased urinary excretion with increasing hydroxy acid content. The diet enriched with milk components reduced absorption by a factor of 5. Potatoes increased absorption and retention by a factor 5, not necessarily due to the effect of phytate. Fasting for 12 or 24 h increased retention and absorption by factors of about 3 and 10, respectively. Data obtained in baboons when low masses of neptunium were administered suggest that the f1 factor used by ICRP should be decreased. However, fasting as encountered in certain nutritional habits is a factor to be taken into consideration.
在pH值为1的硝酸镎溶液经胃内给药后，测定了狒狒体内镎的吸收和滞留情况。研究了剂量、饮食和禁食对吸收的影响。在较高剂量水平（400 - 800微克镎/千克）时，吸收率约为1%；在较低剂量摄入（0.0009 - 0.005微克镎/千克）时，吸收率降低了10至20倍。添加氧化剂（Fe3+）可增加胃肠道吸收，并支持在摄入亏损质量时镎（V）被还原的假说。缺乏或富含羟基酸的饮食并未改变镎的滞留情况，但随着羟基酸含量增加，尿排泄量增加。富含牛奶成分的饮食使吸收率降低了5倍。土豆使吸收和滞留增加了5倍，这不一定是由于植酸盐的作用。禁食12或24小时分别使滞留和吸收增加了约3倍和10倍。在给予低剂量镎时，从狒狒身上获得的数据表明，国际辐射防护委员会（ICRP）使用的f1因子应降低。然而，某些饮食习惯中出现的禁食是一个需要考虑的因素。
