Sullivan M F, Miller B M, Ryan J L
Radiat Res. 1983 Apr;94(1):199-209.
Absorption and retention of plutonium were determined in mice after intragastric administration of either 6 X 10(-4) or 1.5 mg/kg in bicarbonate, citrate, or nitrate media. At the higher concentration, absorption of the citrate was greater than that of the nitrate; at the lower concentration, chemical form was not an important factor in absorption. Concentration and chemical form had much less influence on absorption by the neonatal (versus the adult) rat. The transfer factor (f1) for neonates was between one and two orders of magnitude higher than for adults. Absorption and retention of neptunium were determined in rats and/or mice after intragastric administration at doses ranging from 2.2 X 10(-7) to 43 mg/kg in nitrate solutions of pH 1.5. At the higher concentrations, absorption was 1.5 to 2.7%. For lower concentrations, absorption was 25 to 65 times less. In contrast to results obtained in adult animals, absorption of neptunium by neonates decreased with increasing dose. The data obtained in adult animals suggest that the f1 factor recommended by the ICRP for plutonium should be increased by a factor of 10, but the neptunium f1 factor, in contrast, should be decreased by a factor of 10.
在小鼠经胃内给予碳酸氢盐、柠檬酸盐或硝酸盐介质中6×10⁻⁴或1.5 mg/kg的钚后，测定了钚的吸收和滞留情况。在较高浓度下，柠檬酸盐的吸收大于硝酸盐；在较低浓度下，化学形式不是吸收的重要因素。浓度和化学形式对新生（与成年）大鼠吸收的影响要小得多。新生大鼠的转移因子（f1）比成年大鼠高1至2个数量级。在大鼠和/或小鼠经胃内给予pH值为1.5的硝酸盐溶液中剂量范围为2.2×10⁻⁷至43 mg/kg的镎后，测定了镎的吸收和滞留情况。在较高浓度下，吸收为1.5%至2.7%。对于较低浓度，吸收减少25至65倍。与成年动物获得的结果相反，新生动物对镎的吸收随剂量增加而降低。成年动物获得的数据表明，国际辐射防护委员会（ICRP）推荐的钚的f1因子应增加10倍，但相比之下，镎的f1因子应降低10倍。
