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[使用甲硝唑提高大鼠肉瘤-45的放射治疗效果]

[Increase in the effectiveness of irradiating sarcoma-45 in rats using metronidazole].

作者信息

Vepkhvadze N R

出版信息

Radiobiologiia. 1984 Jan-Feb;24(1):92-4.

PMID:6709852
Abstract

A single exposure to ionizing radiation combined with the administration of metronidazole accelerated the regression of sarcoma-45 and increased the number of animals with fully regressed tumors as compared to control rats exposed to radiation alone. The maximum effect was registered when tumors were irradiated 90 min after the administration of metronidazole. With fractionated irradiation the radiosensitizing effect of metronidazole was less pronounced.

摘要

单次电离辐射与甲硝唑联合使用，与仅接受辐射的对照大鼠相比，加速了肉瘤-45的消退，并增加了肿瘤完全消退的动物数量。在给予甲硝唑90分钟后对肿瘤进行照射时，观察到最大效果。对于分次照射，甲硝唑的放射增敏作用不太明显。

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