Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, 202002, India.
Bull Environ Contam Toxicol. 2023 Apr 12;110(4):79. doi: 10.1007/s00128-023-03714-8.
The current study was performed to explore potential toxic effect of nickel oxide nanoparticles (NiO NPs) on muscle tissue of catfish, Heteropneustes fossilis. Fishes were exposed to different concentrations of NiO NPs (12 mg/L, 24 mg/L, 36 mg/L and 48 mg/L) for a period of 14 days. Results revealed that NiO NPs caused significant increase in Ni accumulation, metallothionein content, lipid peroxidation and activity of different antioxidant enzymes (catalase, glutathione s transferase and glutathione reductase) while decrease in activity of superoxide dismutase (p < 0.05). Data also reported induction of Na/K ATPase activity initially and then its decrease in concentration dependent manner. Fourier transform infrared spectroscopy revealed shift and changes in spectra of muscle of NiO NPs treated fishes. Fluctuations in activity of aspartate amino transferase, alanine amino transferase and alkaline phosphatase were also noticed. Nutritional contents like protein, lipid, and moisture significantly reduced while glucose and ash percent increased.
本研究旨在探讨纳米氧化镍（NiO NPs）对鲶鱼（Heteropneustes fossilis）肌肉组织的潜在毒性作用。实验将鲶鱼暴露于不同浓度的 NiO NPs（12mg/L、24mg/L、36mg/L 和 48mg/L）中 14 天。结果表明，NiO NPs 导致 Ni 积累、金属硫蛋白含量、脂质过氧化和不同抗氧化酶（过氧化氢酶、谷胱甘肽 S 转移酶和谷胱甘肽还原酶）活性显著增加，而超氧化物歧化酶（SOD）活性降低（p<0.05）。数据还表明，Na/K-ATP 酶活性最初升高，然后呈浓度依赖性降低。傅里叶变换红外光谱显示，NiO NPs 处理的鱼类肌肉的光谱发生了偏移和变化。天冬氨酸氨基转移酶、丙氨酸氨基转移酶和碱性磷酸酶的活性也发生了波动。蛋白质、脂肪和水分等营养成分显著减少，而葡萄糖和灰分百分比增加。
