Department of Pharmacy, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Bandarsindri, Ajmer, Rajasthan, 305817, India.
Department of Pharmacy, Birla Institute of Technology and Science, Pilani Hyderabad Campus, Jawahar Nagar, Kapra Mandal, Medchal District, Telangana, 500078, India.
AAPS PharmSciTech. 2023 Apr 11;24(4):102. doi: 10.1208/s12249-023-02555-2.
Glioblastoma multiforme (also known as glioblastoma; GBM) is one of the most malignant types of brain tumors that occurs in the CNS. Treatment strategies for glioblastoma are majorly comprised of surgical resection, radiotherapy, and chemotherapy along with combination therapy. Treatment of GBM is itself a tedious task but the involved barriers in GBM are one of the main impediments to move one step closer to the treatment of GBM. Basically, two of the barriers are of utmost importance in this regard, namely blood brain barrier (BBB) and blood brain tumor barrier (BBTB). This review will address different challenges and barriers in the treatment of GBM along with their etiology. The role and recent progress of lipid-based nanocarriers like liposomes, solid lipid nanocarriers (SLNs), nanostructured lipid carriers (NLCs), lipoplexes, and lipid hybrid carriers in the effective management of GBM will be discussed in detail.
多形性胶质母细胞瘤（也称为胶质母细胞瘤；GBM）是中枢神经系统中最恶性的脑肿瘤之一。胶质母细胞瘤的治疗策略主要包括手术切除、放疗和化疗以及联合治疗。GBM 的治疗本身就是一项艰巨的任务，但 GBM 中涉及的障碍是接近 GBM 治疗的主要障碍之一。基本上，这方面最重要的两个障碍是血脑屏障（BBB）和血脑肿瘤屏障（BBTB）。本综述将讨论 GBM 治疗中的不同挑战和障碍及其病因。将详细讨论脂质纳米载体（如脂质体、固体脂质纳米载体（SLN）、纳米结构脂质载体（NLC）、脂质体、脂质杂化载体）在有效管理 GBM 中的作用和最新进展。
